Document Detail

Bone marrow-derived CD45+ and CD45- cells reside in skeletal muscle.
MedLine Citation:
PMID:  12482405     Owner:  NLM     Status:  MEDLINE    
In this report we examined the kinetics of accumulation in muscle tissue of donor-derived CD45+ and CD45- cells from one to several weeks post-bone marrow transplantation. Only after hemopoiesis is fully reconstituted are CD45+ cells recovered from muscle tissue in proportions similar to ones we reported earlier in non-transplanted mice. Furthermore, using marked donor bone marrow cells, we document that in addition to CD45+ cells, donor-derived CD45- cells with certain phenotypic characteristics progressively accumulate in muscle post-transplantation. The turnover rate and physiologic roles of these populations in muscle are unclear and require further study.
Surasit Issarachai; Gregory V Priestley; Betty Nakamoto; Thalia Papayannopoulou
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Blood cells, molecules & diseases     Volume:  29     ISSN:  1079-9796     ISO Abbreviation:  Blood Cells Mol. Dis.     Publication Date:    2002 Jul-Aug
Date Detail:
Created Date:  2002-12-16     Completed Date:  2003-08-05     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9509932     Medline TA:  Blood Cells Mol Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  69-72     Citation Subset:  IM    
Division of Hematology, University of Washington, Box 357710, Seattle, WA 98195-7710, USA.
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MeSH Terms
Antigens, CD45 / analysis*
Bone Marrow Cells / cytology*,  immunology
Bone Marrow Transplantation*
Cell Movement
Graft Survival
Mice, Transgenic
Muscle Fibers, Skeletal / immunology
Muscle, Skeletal / cytology*
Transplantation Chimera
Reg. No./Substance:
EC, CD45

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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