Document Detail

Bone marrow-derived CD45+ and CD45- cells reside in skeletal muscle.
MedLine Citation:
PMID:  12482405     Owner:  NLM     Status:  MEDLINE    
In this report we examined the kinetics of accumulation in muscle tissue of donor-derived CD45+ and CD45- cells from one to several weeks post-bone marrow transplantation. Only after hemopoiesis is fully reconstituted are CD45+ cells recovered from muscle tissue in proportions similar to ones we reported earlier in non-transplanted mice. Furthermore, using marked donor bone marrow cells, we document that in addition to CD45+ cells, donor-derived CD45- cells with certain phenotypic characteristics progressively accumulate in muscle post-transplantation. The turnover rate and physiologic roles of these populations in muscle are unclear and require further study.
Surasit Issarachai; Gregory V Priestley; Betty Nakamoto; Thalia Papayannopoulou
Related Documents :
24228385 - In vitro cytotoxicity testing of new generation oxazaphosphorines against human histioc...
23166055 - Hydrogels as feeder-free scaffolds for long-term self-renewal of mouse induced pluripot...
25015825 - The ability to rearrange dual tcrs enhances positive selection, leading to increased al...
23934155 - Osteoblast-adipocyte lineage plasticity in tissue development, maintenance and pathology.
3958135 - Role of natural killer cytotoxic factors in the mechanism of target-cell killing by nat...
1783475 - Changes in leukocyte recirculation, nk cell activity, and hla-dr expression in peripher...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Blood cells, molecules & diseases     Volume:  29     ISSN:  1079-9796     ISO Abbreviation:  Blood Cells Mol. Dis.     Publication Date:    2002 Jul-Aug
Date Detail:
Created Date:  2002-12-16     Completed Date:  2003-08-05     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9509932     Medline TA:  Blood Cells Mol Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  69-72     Citation Subset:  IM    
Division of Hematology, University of Washington, Box 357710, Seattle, WA 98195-7710, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Antigens, CD45 / analysis*
Bone Marrow Cells / cytology*,  immunology
Bone Marrow Transplantation*
Cell Movement
Graft Survival
Mice, Transgenic
Muscle Fibers, Skeletal / immunology
Muscle, Skeletal / cytology*
Transplantation Chimera
Reg. No./Substance:
EC, CD45

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Comprehensive analysis of blood coagulation pathways in teleostei: evolution of coagulation factor g...
Next Document:  Protein C pathway impairment in nonsymptomatic cigarette smokers.