Document Detail

Bone marrow biopsy findings in childhood anemia: prevalence of transient erythroblastopenia of childhood.
MedLine Citation:
PMID:  9674545     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Bone marrow examination is rarely required for the diagnosis of childhood anemia, and its diagnostic utility in this setting is unknown. DESIGN: Marrow specimens from 25 children aged 11 days to 12 years were reviewed to determine the cause of unexplained anemia. RESULTS: These samples comprised only 2% of pediatric marrow examinations. Hematocrits ranged from 0.12 to 0.31 (mean 0.23). Marrow findings included erythroid hypoplasia (12 of 25, 48%) and hyperplasia (11 of 25, 44%), dyserythropoiesis (2 cases), ringed sideroblasts (2 cases), lymphocytosis (3 cases), and megaloblastic change (1 case). Final diagnoses were transient erythroblastopenia of childhood (15 cases, 60%); iron deficiency and sideroblastic anemia (2 cases each); and congenital dyserythropoietic anemia, anemia of chronic disease, hereditary spherocytosis, and intra-abdominal hemorrhage (1 case each). In two patients, a definitive diagnosis was never made. CONCLUSIONS: Marrow examination contributed to a specific diagnosis in childhood anemia in 92% of cases; the most common diagnosis in this population was transient erythroblastopenia of childhood.
D C Farhi; E L Luebbers; N S Rosenthal
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Archives of pathology & laboratory medicine     Volume:  122     ISSN:  0003-9985     ISO Abbreviation:  Arch. Pathol. Lab. Med.     Publication Date:  1998 Jul 
Date Detail:
Created Date:  1998-07-30     Completed Date:  1998-07-30     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7607091     Medline TA:  Arch Pathol Lab Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  638-41     Citation Subset:  AIM; IM    
Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, USA.
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MeSH Terms
Anemia / diagnosis,  pathology*
Anemia, Dyserythropoietic, Congenital / diagnosis
Anemia, Iron-Deficiency / diagnosis
Anemia, Sideroblastic / diagnosis
Bone Marrow / pathology*
Erythroblasts / pathology*
Spherocytosis, Hereditary / diagnosis

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