| Bone marrow CD34+ cell count is predictive for adequate peripheral progenitor cell collection. | |
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MedLine Citation:
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PMID: 15607364 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Several studies have investigated the influence of clinical and biological variables on mobilisation of peripheral blood progenitor cells (PBPCs). The aim of this study was to evaluate the role of steady-state bone marrow (BM) CD34+ cells as a predictive parameter of PBPC yield. We studied 90 patients with multiple myeloma (MM) (41 patients), non-Hodgkin's lymphoma (NHL) (25 patients) or acute myeloid leukaemia (AML) (24 patients), mobilised with chemotherapy and growth factor. The median time from first treatment to mobilisation was 5 months. Only one patient was previously exposed to alkylating agents. The median BM CD34+ count at mobilisation was 833 microl(-1) (range: 1.4-15.540) corresponding to 1.51% of mononuclear cells (range: 0.02-8.6). Sixty-six patients (73%) reached the optimal target of 4 x 10(6) kg(-1) CD34+ cells with 1 (18 patients), 2 (42 patients) or 3 leukaphereses (6 patients). Eleven patients (12%) mobilised less than 4 x 10(6) kg(-1) CD34+ cells and 13 (15%) failed mobilisation. Among the laboratory and clinical parameters evaluated at the time of mobilisation, only BM CD34+ count was a predictive factor for adequate collection (P = 0.04), particularly in MM patients (P = 0.003). In this setting, a BM concentration of CD34+ cells lower than 66 microL(-1) was associated with a higher probability of inadequate collection. |
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Authors:
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Alessandro Corso; Marzia Varettoni; Silvia Mangiacavalli; Patrizia Zappasodi; Catherine Klersy; Chiara Rusconi; Emile Colucci; Angela Lorenzi; Daniela Troletti; Erica Consensi; Mario Lazzarino |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Leukemia research Volume: 29 ISSN: 0145-2126 ISO Abbreviation: Leuk. Res. Publication Date: 2005 Feb |
Date Detail:
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Created Date: 2004-12-20 Completed Date: 2005-02-14 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7706787 Medline TA: Leuk Res Country: England |
Other Details:
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Languages: eng Pagination: 159-63 Citation Subset: IM |
Affiliation:
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Division of Hematology, IRCCS Policlinico San Matteo, University of Pavia, Via Golgi 2, 27100 Pavia, Italy. a.corso@smatteo.pv.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Antigens, CD34 / analysis, biosynthesis* Antineoplastic Combined Chemotherapy Protocols / adverse effects, pharmacology Blood Cell Count* Bone Marrow Cells / cytology*, drug effects, physiology Female Filgrastim / adverse effects, pharmacology Hematopoietic Stem Cell Mobilization / methods* Hematopoietic Stem Cells / cytology*, drug effects Humans Leukemia, Myeloid, Acute / blood, drug therapy Lymphoma, Non-Hodgkin / blood, drug therapy Male Middle Aged Multiple Myeloma / blood, drug therapy Multivariate Analysis Predictive Value of Tests |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD34; 121181-53-1/Filgrastim |
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