Document Detail

Bone loss or lost bone: rationale and recommendations for the diagnosis and treatment of early postmenopausal bone loss.
MedLine Citation:
PMID:  19968915     Owner:  NLM     Status:  MEDLINE    
Recent reports suggest that bone loss begins during late perimenopause at a dramatic rate, even before estrogen levels plummet. During the ensuing 5 years, there is evidence of the beginnings of microarchitectural deterioration, which impacts bone strength and ultimately enhances its propensity to fracture. The diagnosis of osteoporosis based on T-scores alone, or through stratification for a high fracture risk by FRAX, excludes these women who are rapidly losing bone. Because all antiosteoporosis therapies, in particular bisphosphonates, reduce bone loss, we propose aggressive, likely short-term therapy with a goal to reduce bone loss, stabilize bone density, and prevent microarchitectural deterioration.
Mone Zaidi; Charles H Turner; Ernesto Canalis; Roberto Pacifici; Li Sun; Jameel Iqbal; X Edward Guo; Stuart Silverman; Solomon Epstein; Clifford J Rosen
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Current osteoporosis reports     Volume:  7     ISSN:  1544-2241     ISO Abbreviation:  Curr Osteoporos Rep     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2009-12-08     Completed Date:  2010-02-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101176492     Medline TA:  Curr Osteoporos Rep     Country:  United States    
Other Details:
Languages:  eng     Pagination:  118-26     Citation Subset:  IM    
The Mount Sinai Bone Program, Box 1055, Mount Sinai School of Medicine, One Gustave Levy Place, New York, NY 10029, USA.
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MeSH Terms
Bone Density
Bone Density Conservation Agents / therapeutic use
Bone Remodeling
Fractures, Spontaneous / etiology,  prevention & control
Osteoporosis, Postmenopausal / diagnosis*,  drug therapy*,  physiopathology
Risk Assessment
Reg. No./Substance:
0/Bone Density Conservation Agents

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