Document Detail


Bone lead and blood lead levels in relation to baseline blood pressure and the prospective development of hypertension: the Normative Aging Study.
MedLine Citation:
PMID:  11159162     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Between 1991 and 1997, the authors studied 833 participants of the Normative Aging Study in a substudy of bone lead levels (measured by K-shell x-ray fluorescence), blood lead levels, and hypertension. Among these subjects, 337 were classified as normotensive, and 182 and 314 were classified as having borderline and definite hypertension, respectively, at baseline. These bone and blood lead levels were typical of those of community-exposed men. Among the 519 subjects with no history of definite hypertension at baseline, cross-sectional analyses revealed positive associations between systolic blood pressure and bone lead levels. Of the 474 subjects who were free from definite hypertension at baseline and had follow-up data, 74 new cases of definite hypertension were reported. Baseline bone lead levels were positively associated with incidence of hypertension. In proportional hazards models that controlled for age, age squared, body mass index, and family history of hypertension, an increase in patella (trabecular) lead from the midpoint of the lowest quintile to that of the highest quintile was associated with a rate ratio of definite hypertension of 1.71 (95% confidence interval: 1.08, 2.70). No association was found with blood lead level. These results support the hypothesis that cumulative exposure to lead, even at low levels sustained by the general population, may increase the risk of hypertension.
Authors:
Y Cheng; J Schwartz; D Sparrow; A Aro; S T Weiss; H Hu
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of epidemiology     Volume:  153     ISSN:  0002-9262     ISO Abbreviation:  Am. J. Epidemiol.     Publication Date:  2001 Jan 
Date Detail:
Created Date:  2001-02-06     Completed Date:  2001-02-22     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7910653     Medline TA:  Am J Epidemiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  164-71     Citation Subset:  IM    
Affiliation:
Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Blood Pressure / drug effects*
Body Mass Index
Bone and Bones / chemistry*
Environmental Exposure / adverse effects*,  analysis*
Follow-Up Studies
Humans
Hypertension / chemically induced*,  classification,  diagnosis,  epidemiology
Incidence
Lead / adverse effects*,  analysis*,  blood
Lead Poisoning / blood,  complications*,  diagnosis*
Male
Middle Aged
Proportional Hazards Models
Questionnaires
Regression Analysis
Risk Factors
Severity of Illness Index
Spectrometry, X-Ray Emission
Grant Support
ID/Acronym/Agency:
2 P30 ES 00002/ES/NIEHS NIH HHS; ES05257-06A1/ES/NIEHS NIH HHS; P42-ES05947/ES/NIEHS NIH HHS
Chemical
Reg. No./Substance:
7439-92-1/Lead

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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