Document Detail

Bone health and deterioration in quality of life among participants from the Hertfordshire cohort study.
MedLine Citation:
PMID:  20024529     Owner:  NLM     Status:  MEDLINE    
INTRODUCTION: Osteoporosis is associated with decreased quality of life, although it has been difficult to evaluate the confounding effects of fracture and co-morbidity. Having previously shown that male osteoporotics have poorer health than counterparts with normal bone mineral density, even after adjustment for co-morbidity and prior fracture, we assessed quality of life in both groups 4 years apart.
METHODS: Four hundred and ninety-eight men and 468 women completed questionnaires detailing lifestyle factors, co-morbidities and quality of life (SF-36) before undergoing bone density measurements at the lumbar spine and total femur. At follow-up 4 years later, 322 men and 320 women were reassessed.
RESULTS: Multinomial logistic regression confirmed deterioration in mental health over follow-up in osteoporotic men compared with other groups (relative rate ratio=5.78, 95% CI 1.78-19.2). These patterns were not apparent among women.
CONCLUSIONS: Men with lower bone density at baseline had poorer quality of life some 4 years later, even after adjustment for co-morbidity and fracture. This may reflect secondary osteoporosis in men (due to alcohol or hypogonadism).
E M Dennison; K A Jameson; H E Syddall; H J Martin; J Cushnaghan; A Aihie Sayer; C Cooper
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-12-19
Journal Detail:
Title:  Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA     Volume:  21     ISSN:  1433-2965     ISO Abbreviation:  Osteoporos Int     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-09-29     Completed Date:  2011-04-28     Revised Date:  2014-02-19    
Medline Journal Info:
Nlm Unique ID:  9100105     Medline TA:  Osteoporos Int     Country:  England    
Other Details:
Languages:  eng     Pagination:  1817-24     Citation Subset:  IM    
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MeSH Terms
Absorptiometry, Photon / methods
Bone Density / physiology*
Cohort Studies
Femur / physiopathology
Follow-Up Studies
Life Style
Lumbar Vertebrae / physiopathology
Mental Disorders / etiology
Middle Aged
Osteoporosis / physiopathology,  psychology,  rehabilitation*
Quality of Life*
Grant Support
MC_UP_A620_1014//Medical Research Council; MC_UP_A620_1015//Medical Research Council; //Arthritis Research UK; //Medical Research Council

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