| Bone healing regulated by nitric oxide: an experimental study in rats. | |
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MedLine Citation:
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PMID: 12439279 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Nitric oxide has many functions in wound healing and metabolism of bone. In the current study the role of nitric oxide on bone healing was investigated. Thirty-six young adult male Sprague-Dawley rats were divided into three groups: control, nitroso-bovine serum albumin, and aminoguanidine. Five millimeter segmental defects were created in the middle of the right femora. A polyethylene plate and screw posts were used for rigid fixation. Demineralized bone matrix served as the graft material in all groups. Nitroso-bovine serum albumin (an active nitric oxide congener) carried by demineralized bone matrix was applied locally at the defect in the nitroso-bovine serum albumin group. Aminoguanidine (an inducible nitric oxide synthase inhibitor) group received oral aminoguanidine treatment. Formation and healing of bone were determined by radiographic and histologic analyses. In comparison to the control group the healing rate was faster in both experimental groups as indicated by radiographic and histologic data. If accompanied by bone graft with a suitable delivery system, nitric oxide may be useful as a therapeutic adjuvant in clinical situations when local formation of bone is needed. Moreover, when combined appropriately, treatment with orthotopic nitric oxide supplementation and systemic inducible nitric oxide synthase inhibition may enhance bone healing. |
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Authors:
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Yasemin Baldik; Ufuk Talu; Levent Altinel; Hatice Bilge; Misten Demiryont; Gulcin Aykac-Toker |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Clinical orthopaedics and related research Volume: - ISSN: 0009-921X ISO Abbreviation: Clin. Orthop. Relat. Res. Publication Date: 2002 Nov |
Date Detail:
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Created Date: 2002-11-19 Completed Date: 2002-12-12 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0075674 Medline TA: Clin Orthop Relat Res Country: United States |
Other Details:
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Languages: eng Pagination: 343-52 Citation Subset: AIM; IM |
Affiliation:
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Department of Biochemistry, University of Istanbul, Istanbul Medical Faculty, Istanbul, Turkey. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Administration, Topical Animals Bone Matrix Bone and Bones / physiology* Drug Carriers Femur / physiology, surgery Guanidines / pharmacology Male Nitric Oxide / administration & dosage, physiology* Nitric Oxide Donors / pharmacology Nitric Oxide Synthase / antagonists & inhibitors Nitric Oxide Synthase Type II Rats Rats, Sprague-Dawley Serum Albumin, Bovine / administration & dosage Sodium Nitrite / administration & dosage Wound Healing / drug effects, physiology* |
| Chemical | |
Reg. No./Substance:
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0/Drug Carriers; 0/Guanidines; 0/Nitric Oxide Donors; 0/Serum Albumin, Bovine; 10102-43-9/Nitric Oxide; 7632-00-0/Sodium Nitrite; 79-17-4/pimagedine; EC 1.14.13.39/Nitric Oxide Synthase; EC 1.14.13.39/Nitric Oxide Synthase Type II; EC 1.14.13.39/Nos2 protein, rat |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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