Document Detail


Bone graft and bone graft substitutes in spine surgery: current concepts and controversies.
MedLine Citation:
PMID:  23281471     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Iliac crest bone graft has long been the standard adjunct used in spine fusion surgery. This graft provides osteogenic, osteoinductive, and osteoconductive elements that aid in creation of a fusion mass. However, morbidity associated with bone graft harvest has led surgeons to seek other potential adjuncts, including bone morphogenetic proteins, demineralized bone matrix, and graft expanders such as synthetic bone graft and allograft. Knowledge of fusion biology is required to understand the benefits and limitations of these agents, which promote fusion via one of four mechanisms: osteogenesis, osteoinduction, osteoconduction, and osteopromotion. Although bone morphogenetic proteins have shown a clear ability to aid in bone formation and successful fusion, recent concern regarding their safety has tempered enthusiasm regarding their use.
Authors:
Gregory Grabowski; Chris A Cornett
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of the American Academy of Orthopaedic Surgeons     Volume:  21     ISSN:  1067-151X     ISO Abbreviation:  J Am Acad Orthop Surg     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-01-02     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9417468     Medline TA:  J Am Acad Orthop Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  51-60     Citation Subset:  IM    
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