Document Detail

Bone development and inflammatory disease is regulated by AP-1 (Fos/Jun).
MedLine Citation:
PMID:  19995753     Owner:  NLM     Status:  MEDLINE    
The Fos and Jun proteins are members of the AP-1 transcription factor complex, which is a central regulator for many cellular functions. This paper summarises the important functions of Fos proteins in bone development, with special emphasis on the Fos-related proteins Fra-1 and Fra-2. These factors determine the functions of osteoblasts and osteoclasts and regulate cytokine signalling during bone development. Likewise, the Jun proteins control the expression of cytokines and chemokines and are probably causally involved in inflammatory skin diseases such as psoriasis. Investigations into the molecular mechanisms responsible for skin inflammation have revealed that Jun proteins control cytokine expression, such as granulocyte colony-stimulating factor, IL-6 and tumour necrosis factor alpha by transcriptional and posttranscriptional pathways. Finally, the paper discusses the relevance of the Jun-dependent mouse model for psoriasis for preclinical studies in the field of anti-angiogenic therapies.
E F Wagner
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Annals of the rheumatic diseases     Volume:  69 Suppl 1     ISSN:  1468-2060     ISO Abbreviation:  Ann. Rheum. Dis.     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2009-12-09     Completed Date:  2010-03-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372355     Medline TA:  Ann Rheum Dis     Country:  England    
Other Details:
Languages:  eng     Pagination:  i86-88     Citation Subset:  IM    
BBVA Foundation-CNIO Cancer Cell Biology Program, Spanish National Cancer Centre (CNIO), c/Melchor Fern?ndez Almagro 3, E-28029 Madrid, Spain.
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MeSH Terms
Angiogenesis Inhibitors / therapeutic use
Bone Development / physiology*
Dermatitis / physiopathology
Disease Models, Animal
Inflammation / drug therapy,  physiopathology*
Proto-Oncogene Proteins c-fos / physiology
Proto-Oncogene Proteins c-jun / physiology
Psoriasis / metabolism
Transcription Factor AP-1 / physiology*
Reg. No./Substance:
0/Angiogenesis Inhibitors; 0/Proto-Oncogene Proteins c-fos; 0/Proto-Oncogene Proteins c-jun; 0/Transcription Factor AP-1

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