Document Detail

Bone densitometry in infants.
MedLine Citation:
PMID:  3292748     Owner:  NLM     Status:  MEDLINE    
Bone mineral mass and density can be measured noninvasively by various absorptiometric procedures. Two methods, dual-photon absorptiometry (DPA) and quantitative computed tomography, have widespread application in adults but only limited use in children. One method, single-photon absorptiometry (SPA), has been used extensively in adults and children and has been modified for use in infants. The radius shaft has been used for most research on infants. However, the difficulty of using older SPA methods on this small bone (4 to 7 mm width) has led a few investigators to measure the shaft of the humerus. The typical precision of measurement in a newborn is about 5% with the use of computerized rectilinear scanners for the radius; older linear scanners have a precision error of 5% to 10% on the humerus. Linear scanners cannot measure precisely the radius in individual neonates. The SPA scans typically take about 5 minutes. The DPA technique using 153Gd has been modified for use on smaller animals (5 to 10 kg monkeys and dogs), but it has not been used on infants because DPA scans take 20 minutes. New methods using x-ray absorptiometry allow rapid (1 minute), precise (1%) measurements in the perinate. The need for a soft tissue bolus is eliminated, and both the axial and peripheral skeletons can be measured with dual-energy x-ray absorptiometry. Ultrasonic measurements do not yet offer adequate precision in the neonate, given the limited biologic range of values.
H S Barden; R B Mazess
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The Journal of pediatrics     Volume:  113     ISSN:  0022-3476     ISO Abbreviation:  J. Pediatr.     Publication Date:  1988 Jul 
Date Detail:
Created Date:  1988-08-22     Completed Date:  1988-08-22     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  172-7     Citation Subset:  AIM; IM; S    
Lunar Radiation Corporation, Madison, Wisconsin, 53713-2698.
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MeSH Terms
Bone and Bones / analysis*
Densitometry / methods*
Infant, Newborn
Minerals / metabolism*
Radionuclide Imaging
Tomography, X-Ray Computed
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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