Document Detail

Bone demineralization in rheumatoid arthritis.
MedLine Citation:
PMID:  3125023     Owner:  NLM     Status:  MEDLINE    
In a group of 210 patients with various stages of rheumatoid arthritis divided according to mobility in 3 groups the highest clavicular cortico-diaphyseal indices were found in the group of exercising patients and the lowest results were in the immobilized group. Double measurements repeated after two years allowed us to establish the annlay loss of cortical bone in each group: -2.19% in the exercising group, -6% in the non-exercising group and -8.94% in the immobilized group. Studying the effect of corticosteroids used in the treatment of rheumatoid arthritis in another group of 153 patients we found lower results of cortical thickness only in dependence on daily dose of this drug and not on the whole used dose. The computed annual loss of cortical bone thickness was 7% in patients on doses 5-10 mg of prednisolone, while in patients on doses 12.5-20 mg of prednisolone the annual loss exceeded 10%.
J Kocián; V Rauser; P Machácek; V Marat
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Czechoslovak medicine     Volume:  10     ISSN:  0139-9179     ISO Abbreviation:  Czech Med     Publication Date:  1987  
Date Detail:
Created Date:  1988-04-07     Completed Date:  1988-04-07     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7805372     Medline TA:  Czech Med     Country:  CZECHOSLOVAKIA    
Other Details:
Languages:  eng     Pagination:  217-25     Citation Subset:  IM; S    
Postgraduate Medical and Pharmaceutical Institute, Prague.
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MeSH Terms
Adrenal Cortex Hormones / adverse effects
Arthritis, Rheumatoid / etiology,  metabolism*
Bone and Bones / metabolism*
Middle Aged
Physical Exertion
Sex Factors
Reg. No./Substance:
0/Adrenal Cortex Hormones; 0/Minerals

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