| Bone and calcium metabolism in subclinical autoimmune hyperthyroidism and hypothyroidism. | |
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MedLine Citation:
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PMID: 14709834 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Bone turnover is reported to increase in favour of resorption in overt hyperthyroidism and the rate of resorption is associated with the levels of thyroid hormones. Hypothyroidism, on the other hand, was shown to cause no disturbance of calcium kinetics and found to associate lower trabecular resorption surfaces and increased bone cortical thickness. Similar studies are very rare in subclinical thyroid disorders and consequently we aimed to examine calcium and bone metabolism in subclinical thyroid disorders. Thirteen patients with subclinical hyperthyroidism secondary to untreated Graves' disease, 20 patients with subclinical hypothyroidism and 10 healthy subjects participated in this survey. Briefly calcium, phosphorus, and creatinine (Cre), urinary deoxypyridinoline (U-DPD) and serum osteocalcin (OC) were measured as biochemical markers for calcium metabolism. Concerning serum Ca and phosphorus levels, there were no differences between three of the groups, but urinary Ca excretion was higher in subclinical hyperthyroid patients compared to control and hypothyroid subjects. Hypothyroid patients had similar U-DPD levels with control subjects (p = 0.218). Serum OC and U-DPD were higher in subclinical hyperthyroid compared to control subjects (p<0.001 and p<0.001 respectively). We demonstrated a higher bone turnover and greater calcium excretion in subclinical hyperthyroid patients. Additionally, we found that subclinical hypothyroidism is not associated with disturbed calcium metabolism. As persistent increase in bone turnover is responsible for accelerated bone loss, patients with Graves' disease may have increased risk for osteoporosis. |
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Authors:
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Gurcan Kisakol; Ahmet Kaya; Sait Gonen; Recep Tunc |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Endocrine journal Volume: 50 ISSN: 0918-8959 ISO Abbreviation: Endocr. J. Publication Date: 2003 Dec |
Date Detail:
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Created Date: 2004-01-07 Completed Date: 2004-09-30 Revised Date: 2005-11-17 |
Medline Journal Info:
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Nlm Unique ID: 9313485 Medline TA: Endocr J Country: Japan |
Other Details:
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Languages: eng Pagination: 657-61 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, Divisions of Endocrinology, Meram Medical Faculty, Selcuk University, Konya, Turkey. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Amino Acids / urine Autoimmune Diseases / blood, metabolism*, physiopathology, urine Biological Markers / analysis Bone Remodeling Bone and Bones / metabolism* Calcium / metabolism*, urine Case-Control Studies Female Graves Disease / blood, metabolism*, physiopathology, urine Humans Hypothyroidism / blood, metabolism*, urine Male Thyroid Hormones / blood |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids; 0/Biological Markers; 0/Thyroid Hormones; 7440-70-2/Calcium; 90032-33-0/deoxypyridinoline |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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