Document Detail


Bone biomarkers help grading severity of coronary calcifications in non dialysis chronic kidney disease patients.
MedLine Citation:
PMID:  22567137     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Osteoprotegerin (OPG) and fibroblast growth factor-23 (FGF23) are recognized as strong risk factors of vascular calcifications in non dialysis chronic kidney disease (ND-CKD) patients. The aim of this study was to investigate the relationships between FGF23, OPG, and coronary artery calcifications (CAC) in this population and to attempt identification of the most powerful biomarker of CAC: FGF23? OPG?
METHODOLOGY/PRINCIPAL FINDINGS: 195 ND-CKD patients (112 males/83 females, 70.8 [27.4-94.6] years) were enrolled in this cross-sectional study. All underwent chest multidetector computed tomography for CAC scoring. Vascular risk markers including FGF23 and OPG were measured. Logistic regression analyses were used to study the potential relationships between CAC and these markers. The fully adjusted-univariate analysis clearly showed high OPG (≥10.71 pmol/L) as the only variable significantly associated with moderate CAC ([100-400[) (OR = 2.73 [1.03;7.26]; p = 0.04). Such association failed to persist for CAC scoring higher than 400. Indeed, severe CAC was only associated with high phosphate fractional excretion (FEPO(4)) (≥38.71%) (OR = 5.47 [1.76;17.0]; p = 0.003) and high FGF23 (≥173.30 RU/mL) (OR = 5.40 [1.91;15.3]; p = 0.002). In addition, the risk to present severe CAC when FGF23 level was high was not significantly different when OPG was normal or high. Conversely, the risk to present moderate CAC when OPG level was high was not significantly different when FGF23 was normal or high.
CONCLUSIONS: Our results strongly suggest that OPG is associated to moderate CAC while FGF23 rather represents a biomarker of severe CAC in ND-CKD patients.
Authors:
Marion Morena; Isabelle Jaussent; Aurore Halkovich; Anne-Marie Dupuy; Anne-Sophie Bargnoux; Leila Chenine; Hélène Leray-Moragues; Kada Klouche; Hélène Vernhet; Bernard Canaud; Jean-Paul Cristol
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-05-02
Journal Detail:
Title:  PloS one     Volume:  7     ISSN:  1932-6203     ISO Abbreviation:  PLoS ONE     Publication Date:  2012  
Date Detail:
Created Date:  2012-05-08     Completed Date:  2012-09-17     Revised Date:  2013-06-25    
Medline Journal Info:
Nlm Unique ID:  101285081     Medline TA:  PLoS One     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e36175     Citation Subset:  IM    
Affiliation:
Laboratoire de Biochimie, CHRU de Montpellier, Montpellier, France.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Biological Markers / blood*
Calcinosis / blood*,  etiology
Coronary Artery Disease / blood*
Cross-Sectional Studies
Female
Fibroblast Growth Factors / blood*
Humans
Kidney Failure, Chronic / blood*,  complications
Logistic Models
Male
Middle Aged
Osteoprotegerin / blood*
Renal Dialysis
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Osteoprotegerin; 0/fibroblast growth factor 23; 62031-54-3/Fibroblast Growth Factors
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