Document Detail


Bone and wound healing in the diabetic patient.
MedLine Citation:
PMID:  20682414     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Impaired soft tissue regeneration and delayed osseous healing are known complications associated with diabetes mellitus with regard to orthopedic surgery, making the management and treatment of diabetic patients undergoing foot and ankle surgery more complex and difficult. At the moment several options are available to address the known issues that complicate the clinical outcomes in these high-risk patients. Using a multifaceted approach, with close attention to intraoperative and perioperative considerations including modification of surgical technique to supplement fixation, local application of orthobiologics, tight glycemic control, administration of supplementary oxygen, and biophysical stimulation via low-intensity pulsed ultrasound and electrical bone stimulation, the impediments associated with diabetic healing can potentially be overcome, to yield improved clinical results for diabetic patients after acute or elective foot and ankle surgery.
Authors:
Siddhant K Mehta; Eric A Breitbart; Wayne S Berberian; Frank A Liporace; Sheldon S Lin
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Foot and ankle clinics     Volume:  15     ISSN:  1558-1934     ISO Abbreviation:  Foot Ankle Clin     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-08-04     Completed Date:  2010-12-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9615073     Medline TA:  Foot Ankle Clin     Country:  United States    
Other Details:
Languages:  eng     Pagination:  411-37     Citation Subset:  IM    
Copyright Information:
2010 Elsevier Inc. All rights reserved.
Affiliation:
Department of Orthopaedics, University of Medicine and Dentistry of New Jersey, Newark, 07103, USA.
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MeSH Terms
Descriptor/Qualifier:
Bone Morphogenetic Proteins / physiology
Bones of Lower Extremity / blood supply,  innervation,  surgery*
Diabetes Complications / physiopathology,  surgery*,  therapy
Electric Stimulation Therapy / methods
Fracture Healing / physiology*
Humans
Orthopedic Procedures / adverse effects,  methods*
Perioperative Care / adverse effects,  methods*
Platelet-Rich Plasma / physiology
Retrospective Studies
Wound Healing / physiology*
Chemical
Reg. No./Substance:
0/Bone Morphogenetic Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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