Document Detail


Bone Tissue Engineering in Oral Surgery: A New Method of Bone Development in Periodontal Surgery.
MedLine Citation:
PMID:  21895495     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
This article describes the development of a new surgical approach to periodontal treatment. Twenty patients who suffered from bone defects without existing bony walls due to adult periodontitis were treated in three different groups using methods of bone tissue engineering. At that time no surgical technique existed that could be applied to those patients to generate new bone. The periodontal surgeries were performed between 2004 and 2008. All patients received follow-up examinations at 6, 12, and 24 months after surgical procedure. Measured parameters were compared to baseline. The surgical approach and the augmentation material have been improved based on the results of the previous group. This strategy was applied because of the ethical fact that a medical treatment of patients has to be carried out with the knowledge and experience of previous settings. All groups received recombinant human bone morphogenetic protein 2 and platelet-rich plasma. The above-mentioned procedure had been approved in other indications in the field of oral and maxillofacial surgery. The first group underwent conventional muco-periosteal flap technique and obtained an augmentation with absorbable collagen sponge (ACS). The second and third groups were treated using endoscopically assisted microsurgery due to wound healing disturbances that appeared in the first group. The augmentation was carried out with demineralized bone matrix (DBM) instead of ACS (group 2) or tricalciumphosphate as a further development instead of DBM (group 3). The radiological control 12 months (group 1), 18 months (group 2), and 2 years (group 3) after surgery proved the following results-first group: 1.7 mm (average) vertical bone development (VBD); second group: 2.5 mm (average) VBD; third group: 3.2 mm (average) VBD. These results of single patient treatment open new ways into periodontal surgery. They have to be confirmed by prospective case series and multicenter studies.
Authors:
Karl-Heinz Schuckert; Magdalena Osadnik
Related Documents :
9040615 - Cricopharyngeal myotomy for neurogenic oropharyngeal dysphagia.
25182865 - The efficacy of risk scores for predicting abdominal wound dehiscence: a case-controlle...
10027375 - Prospective randomized double-blind trial between laparoscopic nissen fundoplication an...
20438915 - Type a esophageal atresia: a critical review of management strategies at a single center.
24763755 - Early addition of topical corticosteroids in the treatment of bacterial keratitis.
22448825 - Adolescent blount disease in obese children treated by eight-plate hemiepiphysiodesis.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-9-6
Journal Detail:
Title:  Tissue engineering. Part C, Methods     Volume:  -     ISSN:  1937-3392     ISO Abbreviation:  -     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-9-7     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101466663     Medline TA:  Tissue Eng Part C Methods     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Institute Indente-Institute of Innovative Oral Surgery and Medicine , Centre for Tissue Engineering, Hannover, Germany .
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Three-dimensional system for the in vitro study of megakaryocytes and functional platelet production...
Next Document:  Effects of Poly(amidoamine) Dendrimers on Ocular Absorption of Puerarin Using Microdialysis.