Document Detail


Bone Resorption Is Increased in Pheochromocytoma Patients and Normalizes following Adrenalectomy.
MedLine Citation:
PMID:  22990094     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Context:The sympathetic nervous system (SNS) controls bone turnover in rodents, but it is uncertain whether a similar role for the SNS exists in humans. Pheochromocytomas are catecholamine-producing neuroendocrine tumors. Because catecholamines are the neurotransmitters of the SNS, we hypothesized that pheochromocytoma patients have increased bone turnover.Objective:Our objective was to compare bone turnover in pheochromocytoma patients and controls.Design and Setting:This retrospective case-control study was performed at the Endocrine Department of the Academic Medical Center of the University of Amsterdam in The Netherlands from 2007 until 2011.Patients:All patients were screened for pheochromocytoma. Cases (n = 21) were identified by 24-h urinary excretion of fractionated metanephrines above the institutional reference value and confirmed by histology after adrenalectomy. All patients screened and diagnosed as not having pheochromocytoma served as controls (n = 126).Main Outcome Measure:The difference in bone turnover markers C-terminal cross-linking telopeptides of collagen type I (CTx) and procollagen type 1 N propeptide (P1NP) between cases and controls was the main outcome measure.Results:CTx concentrations were higher in cases [343 ng/liter; interquartile range (IQR), 295 ng/liter] than in controls (232 ng/liter; IQR, 168 ng/liter; P < 0.001) and decreased after adrenalectomy [before, 365 ng/liter (IQR, 450 ng/liter); after, 290 ng/liter (IQR, 241 ng/liter); P = 0.044]. The effect remained after adjustment for possible confounders. P1NP concentrations did not differ.Conclusions:This study shows that pheochromocytoma patients have increased bone resorption, which normalizes after adrenalectomy. This finding supports the concept of regulation of bone remodeling by the SNS in humans.
Authors:
A G Veldhuis-Vlug; M El Mahdiui; E Endert; A C Heijboer; E Fliers; P H Bisschop
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-9-18
Journal Detail:
Title:  The Journal of clinical endocrinology and metabolism     Volume:  -     ISSN:  1945-7197     ISO Abbreviation:  J. Clin. Endocrinol. Metab.     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-9-19     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375362     Medline TA:  J Clin Endocrinol Metab     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Endocrinology and Metabolism (A.G.V.-V., M.E.M., E.F., P.H.B.) and Department of Clinical Chemistry, Laboratory of Endocrinology (E.E.), Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands; and VU University Medical Center (A.C.H.), Department of Clinical Chemistry, Endocrine Laboratory, 1081 HZ Amsterdam, The Netherlands.
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