| Bone quantitative ultrasound in congenital and acquired childhood multiple pituitary failure. | |
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MedLine Citation:
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PMID: 20381948 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aim of the present study is to investigate bone status by phalangeal quantitative ultrasound (QUS) in a cohort of hypopituitaric pediatric subjects, and to relate measurement outcome to their clinical, laboratory, and therapeutical features. Forty-three hypopituitaric children were submitted to bone measurement by QUS with DBM sonic bone profiler 1200 (IGEA, Carpi, Modena, Italy). This method measures bone transmission time (BTT) and amplitude-dependent speed of sound (AD-SoS) of an ultrasound beam crossing the first four phalanges of the hand and provides respective standard deviation scores (SDS). These two parameters provide information on bone mineral density and structure. Clinical, laboratory and therapeutical features were considered to look for correlations. Overall BTT and AD-SoS SDS were significantly reduced (-0.87 +/- 1.52, p = 0.001, and -0.97 +/- 1.56, p = 0.001) as well as respective height- or bone age-corrected SDS. Bone condition proved significantly worse in subjects with higher number of hormonal deficiencies (p = 0.001 for both parameters) and in those with acquired hypopituitarism (p = 0.020 for BTT and p = 0.010 for AD-SoS) than in those with congenital forms. In participants under growth hormone (GH) treatment, regression analysis revealed that QUS measurement outcome was significantly associated with age at GH therapy start (p = 0.001), time interval before therapy initiation (p = 0.011), treatment duration (p = 0.007) and administered dosage (p = 0.036). Our data show that childhood hypopituitarism is associated with bone morbidity, detectable at QUS measurement independently of potential confounders as stature and bone age. Skeletal impairment is related to acquired hypopituitarism, number of hormonal deficiencies and duration of disease before replacement therapies, whereas GH treatment duration and doses are associated with a better skeletal condition. Phalangeal QUS measurements of BTT and AD-SoS promise as a reliable method for obtaining quantitative measurements of bone disease in individuals with hypopituitarism but more studies are needed for verification. |
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Authors:
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Alessandro Mussa; Marialia Repici; Ludovica Fiore; Gerdi Tuli; Francesco Porta; Patrizia Matarazzo |
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Publication Detail:
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Type: Journal Article Date: 2010-04-09 |
Journal Detail:
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Title: Ultrasound in medicine & biology Volume: 36 ISSN: 1879-291X ISO Abbreviation: Ultrasound Med Biol Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-04-27 Completed Date: 2010-08-05 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0410553 Medline TA: Ultrasound Med Biol Country: England |
Other Details:
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Languages: eng Pagination: 726-32 Citation Subset: IM |
Copyright Information:
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Copyright 2010 World Federation for Ultrasound in Medicine & Biology. Published by Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Pediatrics, University of Torino, Regina Margherita Children Hospital, Torino, Italy. mussa_alessandro@yahoo.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Algorithms Bone Diseases, Metabolic / congenital*, ultrasonography* Female Finger Phalanges / ultrasonography* Humans Hypopituitarism / congenital*, ultrasonography* Image Enhancement / methods Image Interpretation, Computer-Assisted / methods* Male Reproducibility of Results Sensitivity and Specificity Ultrasonography / methods* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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