Document Detail


Bone marrow transplantation for primary immunodeficiency diseases.
MedLine Citation:
PMID:  20307719     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Advances in immunology have led to a breathtaking expansion of recognized primary immunodeficiency diseases (PID) with over 120 disease-related genes identified. In North America alone more than 1000 children have received allogeneic blood or marrow transplant over the past 30 years, with the majority surviving long term. This review presents results and highlights challenges and notable advances, including novel less toxic conditioning regimens, to transplant the more common and severe forms of PID. HLA-matched sibling donors remain the ideal option, however, advances in living donor unrelated HSCT and banked umbilical cord blood grafts provide hope for all children with severe PID.
Authors:
Paul Szabolcs; Marina Cavazzana-Calvo; Alain Fischer; Paul Veys
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Pediatric clinics of North America     Volume:  57     ISSN:  1557-8240     ISO Abbreviation:  Pediatr. Clin. North Am.     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-03-23     Completed Date:  2010-04-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0401126     Medline TA:  Pediatr Clin North Am     Country:  United States    
Other Details:
Languages:  eng     Pagination:  207-37     Citation Subset:  AIM; IM    
Copyright Information:
Copyright 2010 Elsevier Inc. All rights reserved.
Affiliation:
Department of Pediatrics, Pediatric Blood and Marrow Transplant Program, Box 3350, Duke University Medical Center, Durham, NC 27705, USA. szabo001@mc.duke.edu
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MeSH Terms
Descriptor/Qualifier:
Bone Marrow Transplantation / methods*
Humans
Severe Combined Immunodeficiency / mortality,  surgery*
Survival Rate / trends
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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