Document Detail


Bone marrow transplantation for primary immunodeficiency diseases.
MedLine Citation:
PMID:  20307719     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Advances in immunology have led to a breathtaking expansion of recognized primary immunodeficiency diseases (PID) with over 120 disease-related genes identified. In North America alone more than 1000 children have received allogeneic blood or marrow transplant over the past 30 years, with the majority surviving long term. This review presents results and highlights challenges and notable advances, including novel less toxic conditioning regimens, to transplant the more common and severe forms of PID. HLA-matched sibling donors remain the ideal option, however, advances in living donor unrelated HSCT and banked umbilical cord blood grafts provide hope for all children with severe PID.
Authors:
Paul Szabolcs; Marina Cavazzana-Calvo; Alain Fischer; Paul Veys
Related Documents :
12475739 - Is there a role for reduced-intensity haematopoietic stem cell transplantation for indo...
12692619 - Availability of unrelated donors for hematopoietic stem cell transplantation for hemogl...
21042309 - Retrospective study of allogeneic haematopoietic stem-cell transplantation for myelofib...
17506069 - Hepatic veno-occlusive disease after tranexamic acid administration in patients undergo...
16544299 - Human herpesvirus 7 in pediatric hematopoietic stem cell transplantation.
21067259 - Secondary malignancies after hematopoietic stem cell transplantation.
1946129 - Delayed recovery of renal function in patients with acute renal failure due to accelera...
17160959 - Renal recovery after severe acute renal failure.
8830819 - Impact of arterialization on hepatic oxygen supply, tissue energy phosphates, and outco...
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Pediatric clinics of North America     Volume:  57     ISSN:  1557-8240     ISO Abbreviation:  Pediatr. Clin. North Am.     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-03-23     Completed Date:  2010-04-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0401126     Medline TA:  Pediatr Clin North Am     Country:  United States    
Other Details:
Languages:  eng     Pagination:  207-37     Citation Subset:  AIM; IM    
Copyright Information:
Copyright 2010 Elsevier Inc. All rights reserved.
Affiliation:
Department of Pediatrics, Pediatric Blood and Marrow Transplant Program, Box 3350, Duke University Medical Center, Durham, NC 27705, USA. szabo001@mc.duke.edu
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Bone Marrow Transplantation / methods*
Humans
Severe Combined Immunodeficiency / mortality,  surgery*
Survival Rate / trends
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Hematopoietic Stem Cell Transplantation for Hemoglobinopathies: Current Practice and Emerging Trends...
Next Document:  Autologous Hematopoietic Stem Cell Transplantation for Childhood Autoimmune Disease.