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Bone disorders in chronic liver diseases.
MedLine Citation:
PMID:  21104208     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Bone disease is a major complication of chronic liver disease. Osteomalacia is quite uncommon despite low vitamin D levels in the majority of patients with cirrhosis. In contrast, osteoporosis is quite common, occurring in up to 50% of patients. Osteoporosis can result in spontaneous or low-impact fractures in patients with chronic liver diseases, adversely affecting morbidity, quality of life, and survival. The general biology of osteoporosis, including its pathogenesis, diagnostic tools, and rationale for treatment, have been determined largely empirically from studies of postmenopausal women with osteoporosis. Treatment regimens with modification of risk factors, use of vitamin D, and supplementation with calcium and bisphosphonates have been shown to be effective in select groups of patients with chronic liver diseases.
Authors:
Bruce A Luxon
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Current gastroenterology reports     Volume:  13     ISSN:  1534-312X     ISO Abbreviation:  Curr Gastroenterol Rep     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-01-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100888896     Medline TA:  Curr Gastroenterol Rep     Country:  United States    
Other Details:
Languages:  eng     Pagination:  40-8     Citation Subset:  IM    
Affiliation:
Department of Medicine, Georgetown University, Chairman's Office, Suite 5005F PHC, 3800 Reservoir Road, NW, Washington, DC, 20007, USA, Bruce.A.Luxon@gunet.georgetown.edu.
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