| Bombesin suppresses feeding in rats. | |
| | |
MedLine Citation:
|
PMID: 492336 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Bombesin (BBS) is a tetradecapeptide originally isolated from amphibian skin1. BBS-like immunoactivity is widely distributed in mammalian gut2-5, and plasma levels have been shown to rise sharply following feeding (ref. 6 and V. Erspamer, personal communication). The physiological actions of BBS are unknown. We have previously shown that the classic gut hormone cholecystokinin (CCK) is a powerful and specific suppressor of food intake7-9. Although CCK and BBS lack common amino acid sequences, they have certain common actions on gut viscera10,11. We have now shown that BBS also suppresses food intake, and we compare its action with that of CCK. |
| | |
Authors:
|
J Gibbs; D J Fauser; E A Rowe; B J Rolls; E T Rolls; S P Maddison |
Related Documents
:
|
1773096 - Feedback in the rabbit's central circadian system, revealed by the changes in its free-... 15836896 - Satiety enhancement by selective orexin-1 receptor antagonist sb-334867: influence of t... 3467386 - Estrogens and the leydig ltw(m) tumor syndrome: anorexia and diet aversions attenuated ... 14576176 - The evolutionarily conserved gonadotropin-releasing hormone ii modifies food intake. 464056 - Changes in gastrin levels, food intake, and duodenal mucosal growth during lactation. 12835056 - Characterization of light gluten and light steep water from a corn wet milling plant. |
Publication Detail:
|
Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: Nature Volume: 282 ISSN: 0028-0836 ISO Abbreviation: Nature Publication Date: 1979 Nov |
Date Detail:
|
Created Date: 1979-12-29 Completed Date: 1979-12-29 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0410462 Medline TA: Nature Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 208-10 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Behavior, Animal / drug effects Bombesin / pharmacology* Cholecystokinin / pharmacology Depression, Chemical Drinking Behavior / drug effects Feeding Behavior / drug effects* Male Peptides / pharmacology* Rats Satiation / drug effects* |
| Chemical | |
Reg. No./Substance:
|
0/Peptides; 31362-50-2/Bombesin; 9011-97-6/Cholecystokinin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Genetic defect in secretion of complement C5 in mice.
Next Document: Inhibition of platelet thrombus formation by chlorpromazine acting to diminish haemolysis.