Document Detail

Bombesin suppresses feeding in rats.
MedLine Citation:
PMID:  492336     Owner:  NLM     Status:  MEDLINE    
Bombesin (BBS) is a tetradecapeptide originally isolated from amphibian skin1. BBS-like immunoactivity is widely distributed in mammalian gut2-5, and plasma levels have been shown to rise sharply following feeding (ref. 6 and V. Erspamer, personal communication). The physiological actions of BBS are unknown. We have previously shown that the classic gut hormone cholecystokinin (CCK) is a powerful and specific suppressor of food intake7-9. Although CCK and BBS lack common amino acid sequences, they have certain common actions on gut viscera10,11. We have now shown that BBS also suppresses food intake, and we compare its action with that of CCK.
J Gibbs; D J Fauser; E A Rowe; B J Rolls; E T Rolls; S P Maddison
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Nature     Volume:  282     ISSN:  0028-0836     ISO Abbreviation:  Nature     Publication Date:  1979 Nov 
Date Detail:
Created Date:  1979-12-29     Completed Date:  1979-12-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0410462     Medline TA:  Nature     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  208-10     Citation Subset:  IM    
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MeSH Terms
Behavior, Animal / drug effects
Bombesin / pharmacology*
Cholecystokinin / pharmacology
Depression, Chemical
Drinking Behavior / drug effects
Feeding Behavior / drug effects*
Peptides / pharmacology*
Satiation / drug effects*
Reg. No./Substance:
0/Peptides; 31362-50-2/Bombesin; 9011-97-6/Cholecystokinin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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