| Bombesin, somatostatin, and related peptides: actions on thermoregulation. | |
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MedLine Citation:
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PMID: 6117485 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Bombesin acts within the anterior hypothalamic preoptic area to interfere with thermoregulation in the rat. The body temperature (Tb) of animals receiving bombesin varies in parallel with ambient temperature (Ta). Bombesin-induced reduction of Tb in animals at low Ta is associated with a marked reduction of oxygen consumption (VO2). Some somatostatin-related peptides, e.g., desAA 1,2,4,5,12,13 [D-Trp8]-somatostatin (ODT8-SS), act within the brain to prevent bombesin-induced reduction of VO2 and Tb. ODT8-SS also produces hyperthermia not associated with an increase in VO2. |
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Authors:
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M R Brown |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Federation proceedings Volume: 40 ISSN: 0014-9446 ISO Abbreviation: Fed. Proc. Publication Date: 1981 Nov |
Date Detail:
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Created Date: 1982-01-09 Completed Date: 1982-01-09 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0372771 Medline TA: Fed Proc Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 2765-8 Citation Subset: IM |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Body Temperature Regulation / drug effects* Bombesin / pharmacology* Dinoprostone Gastrin-Releasing Peptide Hypothalamus / drug effects, physiology* Peptides / pharmacology* Prostaglandins E / pharmacology Rats Somatostatin / analogs & derivatives, pharmacology* Structure-Activity Relationship |
| Grant Support | |
ID/Acronym/Agency:
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AM26741/AM/NIADDK NIH HHS; NS14263/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Peptides; 0/Prostaglandins E; 31362-50-2/Bombesin; 363-24-6/Dinoprostone; 51110-01-1/Somatostatin; 80043-53-4/Gastrin-Releasing Peptide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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