| Bombesin produces hypothermia in insulin treated rats. | |
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MedLine Citation:
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PMID: 2664543 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Previous studies have shown that central injection of bombesin produces hypothermia in food-deprived, but not food satiated rats at normal ambient temperatures. The present study evaluated the effects of bombesin on core body temperature (Tb) and feeding behavior in rats pretreated with insulin. Administration of bombesin (0.25, 0.5, and 1.0 microgram) into the lateral cerebral ventricle produced hypothermia in rats injected with insulin (10 U/kg; i.m.). No significant change in core temperature was observed in control rats following bombesin. Insulin treatments significantly stimulated feeding behavior and the highest dose of bombesin significantly reduced feeding behavior. The results demonstrate bombesin-induced hypothermia under metabolic conditions similar to acute starvation. These findings are consistent with the hypothesis that bombesin-induced hypothermia in food-deprived rats is directly related to the fasting state. |
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Authors:
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A M Babcock; C Barton; L Perez; F Hearndon |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Neuropharmacology Volume: 28 ISSN: 0028-3908 ISO Abbreviation: Neuropharmacology Publication Date: 1989 Apr |
Date Detail:
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Created Date: 1989-08-17 Completed Date: 1989-08-17 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0236217 Medline TA: Neuropharmacology Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 437-40 Citation Subset: IM |
Affiliation:
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Department of Psychology, University of South Alabama, Mobile 36688. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Body Temperature / drug effects* Bombesin / administration & dosage, pharmacology* Eating / drug effects Injections, Intraventricular Insulin / pharmacology* Male Rats Rats, Inbred Strains |
| Chemical | |
Reg. No./Substance:
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11061-68-0/Insulin; 31362-50-2/Bombesin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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