Document Detail


Bombesin in short bowel syndrome.
MedLine Citation:
PMID:  15204957     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Short bowel syndrome comprises the sequel of nutrient, fluid, and weight loss that occurs subsequent to greatly reduced functional surface area of the small intestine. The aim of this study is to investigate the trophic and functional effects of bombesin on remaining gut in rats with experimentally induced short bowel syndrome. Thirty-two rats were allocated randomly and experimental short bowel syndrome was induced by 80% bowel resection in all rats. A regular enteral diet and isocaloric elemental enteral nutrition for 12 days were given in the control group and the elemental nutrition group, respectively. In the bombesin group 10 microg/kg subcutaneous bombesin (t.i.d.) for 10 days with regular enteral diet for 12 days was given. In the elemental nutrition and bombesin group the diet consisted of 10 microg/kg subcutaneous bombesin (t.i.d.) for 10 days with isocaloric elemental enteral nutrition for 12 days was given. All rats underwent physical, histological, and biochemical evaluation. Reduction in weight loss, bowel diameter, fecal fat content, and glycemia, increase in cellularity, and d-xylose absorption were observed in all treatment groups. These changes were more evident in the bombesin treatment groups. Increases in serum protein and albumin levels were seen with bombesin treatment with or without elemental diet, whereas reductions in villous height and crypt depth were observed only with bombesin treatment without elemental diet. Serum calcium, iron, and vitamin B(12) levels were not affected with any treatment. It is concluded that bombesin may be a useful trophic agent contributing to increased absorptive capacity and improved biochemical values even in the absence of elemental nutrition.
Authors:
Ahmet Haldun Uluutku; Mehmet Levhi Akin; Yavuz Kurt; Ergun Yucel; Hakan Cermik; Kadir Avsar; Tuncay Celenk
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Publication Detail:
Type:  Evaluation Studies; Journal Article    
Journal Detail:
Title:  Journal of investigative surgery : the official journal of the Academy of Surgical Research     Volume:  17     ISSN:  0894-1939     ISO Abbreviation:  J Invest Surg     Publication Date:    2004 May-Jun
Date Detail:
Created Date:  2004-06-18     Completed Date:  2004-08-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8809255     Medline TA:  J Invest Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  135-41     Citation Subset:  IM    
Affiliation:
Department of General Surgery, Gulhane Military Medical Academy, Haydarpaşa Teaching Hospital, Istanbul, Turkey.
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MeSH Terms
Descriptor/Qualifier:
Animals
Bombesin / therapeutic use*
Enteral Nutrition / methods
Growth Substances / therapeutic use*
Male
Rats
Recovery of Function
Short Bowel Syndrome / diet therapy,  drug therapy*,  physiopathology
Treatment Outcome
Chemical
Reg. No./Substance:
0/Growth Substances; 31362-50-2/Bombesin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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