Document Detail


Bombesin improves survival from methotrexate-induced enterocolitis.
MedLine Citation:
PMID:  7944667     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: The authors determined whether bombesin could improve survival from methotrexate (MTX)-induced enterocolitis. SUMMARY BACKGROUND DATA: Bombesin prevents gut mucosal atrophy, which is produced by feeding rats an elemental diet. Administration of MTX produces a lethal enterocolitis in rats fed an elemental diet. METHODS: On treatment day 0, 60 rats were divided randomly into three groups and fed an elemental diet (Vivonex TEN, Sandoz, Minneapolis, MN) as the only source of nutrition. Groups were subdivided further to receive either saline or bombesin (10 micrograms/kg, subcutaneously, three times a day) beginning either on day 0 or day 14. Methotrexate (20 mg/kg, intraperitoneally) was given to all rats 14 days after the start of an elemental diet. RESULTS: Bombesin prevented the mucosal atrophy in the ileum produced by the elemental diet and significantly decreased mortality in rats given MTX (whether given as a pretreatment or at the time of MTX administration). CONCLUSION: Bombesin significantly improved survival in a lethal model of MTX-induced enterocolitis, possibly by maintaining gut mucosal structure. Administration of bombesin to patients receiving chemotherapy may be clinically useful in preventing the severe enterocolitis induced by various chemotherapeutic agents.
Authors:
K U Chu; S Higashide; B M Evers; S Rajaraman; J Ishizuka; C M Townsend; J C Thompson
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Annals of surgery     Volume:  220     ISSN:  0003-4932     ISO Abbreviation:  Ann. Surg.     Publication Date:  1994 Oct 
Date Detail:
Created Date:  1994-11-10     Completed Date:  1994-11-10     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0372354     Medline TA:  Ann Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  570-6; discussion 576-7     Citation Subset:  AIM; IM    
Affiliation:
Department of Surgery, University of Texas Medical Branch, Galveston.
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MeSH Terms
Descriptor/Qualifier:
Animals
Atrophy
Bombesin / therapeutic use*
Enterocolitis / chemically induced*,  prevention & control*
Food Additives / adverse effects
Food, Formulated / adverse effects
Ileal Diseases / etiology,  prevention & control
Intestinal Mucosa / pathology
Male
Methotrexate / adverse effects*
Organic Chemicals
Rats
Rats, Inbred F344
Grant Support
ID/Acronym/Agency:
5P01 DK35608/DK/NIDDK NIH HHS; 5R37 DK15241/DK/NIDDK NIH HHS; R29 AG10885/AG/NIA NIH HHS
Chemical
Reg. No./Substance:
0/Food Additives; 0/Organic Chemicals; 31362-50-2/Bombesin; 59-05-2/Methotrexate; 93197-02-5/Vivonex
Comments/Corrections

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