Document Detail


Bombesin and G-17 dose responses in duodenal ulcer and controls.
MedLine Citation:
PMID:  3932039     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Gastric acid and pepsin secretion and serum gastrin concentrations were measured in nine patients with uncomplicated duodenal ulcer (DU) and 10 normal controls in the fasting state and in response to graded doses of bombesin, a tetradecapeptide gastrin releaser, and, for reference, synthetic gastrin G-17. Serum gastrin with bombesin stimulation was significantly greater in duodenal ulcer (maximum 467 pg/ml) than in controls (153 pg/ml), while in seven of the DU group tested gastrin levels after a meal were not different from that seen in five of the normal controls. Gastric acid concentrations and outputs were greater in duodenal ulcer with both stimuli. Secretory responses were then related to serum gastrin levels; despite increasing gastrin levels with bombesin stimulation, peak outputs achieved with bombesin were only 50% of G-17 maximum in normals and up to 90% of maximum in duodenal ulcer. Up to the point of peak response to bombesin, acid and pepsin outputs were the same with exogenous and endogenous gastrin, ie, bombesin acted only via G-17. Furthermore, in direct comparison of duodenal ulcer and normals with G-17 infusion, acid and pepsin outputs related to serum gastrin were congruent up to 75% of duodenal ulcer maximum, at which point normals reached their maximum level. These data have shown that duodenal ulcer patients are not more sensitive to either exogenous or endogenous gastrin; we have also shown regulatory defects in duodenal ulcer patients not previously described: an exaggerated release of gastrin with bombesin stimulation, and a defective inhibition of acid and pepsin secretion with higher doses of bombesin.
Authors:
B I Hirschowitz; L O Tim; C A Helman; E Molina
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Digestive diseases and sciences     Volume:  30     ISSN:  0163-2116     ISO Abbreviation:  Dig. Dis. Sci.     Publication Date:  1985 Nov 
Date Detail:
Created Date:  1985-12-10     Completed Date:  1985-12-10     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7902782     Medline TA:  Dig Dis Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1092-1103     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Bombesin / diagnostic use*
Dose-Response Relationship, Drug
Duodenal Ulcer / metabolism*
Female
Gastric Acid / secretion*
Gastrins / blood*,  diagnostic use*
Hormones / diagnostic use*
Humans
Male
Pepsin A / secretion*
Stimulation, Chemical
Grant Support
ID/Acronym/Agency:
AM09260/AM/NIADDK NIH HHS; MO1RR00032/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Gastrins; 0/Hormones; 31362-50-2/Bombesin; 60748-06-3/gastrin 17; EC 3.4.23.1/Pepsin A

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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