Document Detail

Body-weight regulation in children: a key to obesity physiopathology understanding
MedLine Citation:
PMID:  15049288     Owner:  NLM     Status:  MEDLINE    
Body weight is regulated within a narrow, individualized range despite large daily caloric mismatches. This process which maintains a stable level of body weight is known as adipostat. Peripheral adiposity signals, mainly leptin and ghrelin, communicate the status of energy stores in the body to the hypothalamus, which in turn coordinates adaptive responses to energy imbalances via reciprocal alterations in appetite and energy expenditure. Obese individuals also display behavioral and metabolic adjustments to weight perturbations as if their adipostat attempts to maintain their elevated body-weight. Efforts to reduce the weight of obese subjects from the elevated levels they ordinarily display are frequently ineffective because their adipostat actively resists by stimulating appetite and reducing energy expenditure. These adaptive responses to weight loss may be an explanation to understand the traditional failure of obesity treatment. Strategy of directly altering the energy-regulating system may be a promising therapeutic approach.
P Tounian
Publication Detail:
Type:  English Abstract; Journal Article; Review    
Journal Detail:
Title:  Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie     Volume:  11     ISSN:  0929-693X     ISO Abbreviation:  Arch Pediatr     Publication Date:  2004 Mar 
Date Detail:
Created Date:  2004-03-29     Completed Date:  2004-08-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9421356     Medline TA:  Arch Pediatr     Country:  France    
Other Details:
Languages:  fre     Pagination:  240-4     Citation Subset:  IM    
Service de gastro-entérologie et nutrition pédiatriques, hôpital d'enfants Armand-Trousseau, AP-HP, Paris, France.
Vernacular Title:
Régulation du poids chez l'enfant: application à la compréhension de l'obésité.
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MeSH Terms
Body Weight / physiology*
Energy Metabolism
Obesity / physiopathology*,  therapy

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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