Document Detail

Body weight and mortality among women.
MedLine Citation:
PMID:  7637744     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The relation between body weight and overall mortality remains controversial despite considerable investigation. METHODS: We examined the association between body-mass index (defined as the weight in kilograms divided by the square of the height in meters) and both overall mortality and mortality from specific causes in a cohort of 115,195 U.S. women enrolled in the prospective Nurses' Health Study. These women were 30 to 55 years of age and free of known cardiovascular disease and cancer in 1976. During 16 years of follow-up, we documented 4726 deaths, of which 881 were from cardiovascular disease, 2586 from cancer, and 1259 from other causes. RESULTS: In analyses adjusted only for age, we observed a J-shaped relation between body-mass index and overall mortality. When women who had never smoked were examined separately, no increase in risk was observed among the leaner women, and a more direct relation between weight and mortality emerged (P for trend < 0.001). In multivariate analyses of women who had never smoked and had recently had stable weight, in which the first four years of follow-up were excluded, the relative risks of death from all causes for increasing categories of body-mass index were as follows: body-mass index < 19.0 (the reference category), relative risk = 1.0; 19.0 to 21.9, relative risk = 1.2; 22.0 to 24.9, relative risk = 1.2; 25.0 to 26.9, relative risk = 1.3; 27.0 to 28.9, relative risk = 1.6; 29.0 to 31.9, relative risk = 2.1; and > or = 32.0, relative risk = 2.2 (P for trend < 0.001). Among women with a body-mass index of 32.0 or higher who had never smoked, the relative risk of death from cardiovascular disease was 4.1 (95 percent confidence interval, 2.1 to 7.7), and that of death from cancer was 2.1 (95 percent confidence interval, 1.4 to 3.2), as compared with the risk among women with a body-mass index below 19.0. A weight gain of 10 kg (22 lb) or more since the age of 18 was associated with increased mortality in middle adulthood. CONCLUSIONS: Body weight and mortality from all causes were directly related among these middle-aged women. Lean women did not have excess mortality. The lowest mortality rate was observed among women who weighed at least 15 percent less than the U.S. average for women of similar age and among those whose weight had been stable since early adulthood.
J E Manson; W C Willett; M J Stampfer; G A Colditz; D J Hunter; S E Hankinson; C H Hennekens; F E Speizer
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The New England journal of medicine     Volume:  333     ISSN:  0028-4793     ISO Abbreviation:  N. Engl. J. Med.     Publication Date:  1995 Sep 
Date Detail:
Created Date:  1995-09-14     Completed Date:  1995-09-14     Revised Date:  2010-03-24    
Medline Journal Info:
Nlm Unique ID:  0255562     Medline TA:  N Engl J Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  677-85     Citation Subset:  AIM; IM    
Channing Laboratory, Harvard Medical School, Boston, MA, USA.
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MeSH Terms
Body Constitution
Body Mass Index*
Body Weight*
Cardiovascular Diseases / mortality
Cause of Death
Middle Aged
Multivariate Analysis
Neoplasms / mortality
Prospective Studies
Reference Values
Risk Factors
United States / epidemiology
Weight Gain
Grant Support
Comment In:
ACP J Club. 1996 Mar-Apr;124(2):50
N Engl J Med. 1995 Sep 14;333(11):723-4   [PMID:  7637752 ]
N Engl J Med. 1996 Mar 14;334(11):733   [PMID:  8594441 ]
N Engl J Med. 1996 Mar 14;334(11):732; author reply 733   [PMID:  8594439 ]
N Engl J Med. 1996 Mar 14;334(11):732; author reply 733   [PMID:  8594438 ]
N Engl J Med. 1996 Mar 14;334(11):732; author reply 733   [PMID:  8594440 ]

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