Document Detail

Body weight is more important than family history of hypertension for left ventricular function.
MedLine Citation:
PMID:  2022409     Owner:  NLM     Status:  MEDLINE    
Left ventricular function was studied in young men with a positive family history of hypertension for two generations (n = 15). The findings were compared with three control groups: one age-, sex-, and weight-matched group with a negative family history of hypertension (n = 14); one normotensive control group unselected as regards family history of hypertension (n = 27); and one group also unselected regarding family history of hypertension but selected with blood pressure criteria to have mild blood pressure elevation (n = 59). The group with a positive family history of hypertension, in comparison with the normotensive control group, was heavier, had higher blood pressure, increased left ventricular wall thickness, increased left ventricular mass, and signs of changes in diastolic and systolic left ventricular function. There were no differences in these variables between the group with a positive family history and the other two control groups. Data clearly indicated that subjects with a positive family history of hypertension, as well as subjects with mild blood pressure elevation, were heavier than the normotensive control group. It is not possible to judge, with available data, if the changes in left ventricular morphology and function in the two groups with a different family history of hypertension and in the group with mild blood pressure elevation occurred as a physiological response to the increase in afterload or if the neurohormonal and metabolic disturbances leading to the condition of slight overweight also affected left ventricular function.
M B Suurküla; J Wikstrand; G Berglund; R Sivertsson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Hypertension     Volume:  17     ISSN:  0194-911X     ISO Abbreviation:  Hypertension     Publication Date:  1991 May 
Date Detail:
Created Date:  1991-06-06     Completed Date:  1991-06-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7906255     Medline TA:  Hypertension     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  661-8     Citation Subset:  IM    
Wallenberg Laboratory for Cardiovascular Research, Department of Medicine I, Sahlgrenska Hospital, Gothenburg, Sweden.
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MeSH Terms
Body Mass Index
Body Weight*
Heart Rate
Heart Ventricles
Hypertension / genetics*,  pathology,  physiopathology
Isometric Contraction
Middle Aged
Myocardial Contraction
Myocardium / pathology
Time Factors
Ventricular Function, Left*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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