Document Detail

Body weight gain rate in patients with Parkinson's disease and deep brain stimulation.
MedLine Citation:
PMID:  14639677     Owner:  NLM     Status:  MEDLINE    
We evaluated body weight changes in patients with Parkinson's disease (PD) after electrode implantation for deep brain stimulation (DBS) in the subthalamic nucleus (STN) in relation to clinical improvement. Thirty PD patients who received STN DBS were included (22 men, 8 women; mean age, 60.0 +/- 7.1 years; mean PD duration, 13.5 +/- 3.7 years; mean body mass index [BMI], 21.6 +/- 3.0 kg/m2). Body weight, physical activity, and Unified Parkinson's Disease Rating Scale (UPDRS) scores were noted before and 3 and 12 months after the procedure. Significant weight gain occurred in 29 patients; the mean increase was 14.8 +/- 9.8% of initial body weight in 1 year. Of the patients, 46.5% reported weight gain in the first 3 months, 21.4% gradual weight gain in the first 6 months, and 32.1% a slow increase for 1 year. Mean BMI increased up to 24.7 +/- 3.7 kg/m2. After 1 year, mean UPDRS motor score improved significantly in off and in on; and therapy complications improved by 91.0 +/- 17.0%. BMI changes at 3 and 12 months were significantly correlated to dyskinesia score changes, and levodopa dosage was not. In PD, STN DBS produces not only symptom control, but also weight gain. DBS candidates should be given nutritional counseling before the intervention to prevent rapid and/or excessive weight gain.
Michela Barichella; Agnieszka M Marczewska; Claudio Mariani; Andrea Landi; Antonella Vairo; Gianni Pezzoli
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Movement disorders : official journal of the Movement Disorder Society     Volume:  18     ISSN:  0885-3185     ISO Abbreviation:  Mov. Disord.     Publication Date:  2003 Nov 
Date Detail:
Created Date:  2003-11-25     Completed Date:  2004-03-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8610688     Medline TA:  Mov Disord     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1337-40     Citation Subset:  IM    
Centro per la Malattia di Parkinson ed i Disturbi del Movimento, Parkinson Institute, Istituti Clinici di Perfezionamento, Milan, Italy.
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MeSH Terms
Body Mass Index
Body Weight*
Electric Stimulation / adverse effects,  instrumentation
Middle Aged
Parkinson Disease / diagnosis,  therapy*
Severity of Illness Index
Subthalamic Nucleus / physiology*
Weight Gain*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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