| Body weight control by a high-carbohydrate/low-fat diet slows the progression of diabetic kidney damage in an obese, hypertensive, type 2 diabetic rat model. | |
| | |
MedLine Citation:
|
PMID: 20700413 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
Obesity is one of several factors implicated in the genesis of diabetic nephropathy (DN). Obese, hypertensive, type 2 diabetic rats SHR/NDmcr-cp were given, for 12 weeks, either a normal, middle-carbohydrate/middle-fat diet (MC/MF group) or a high-carbohydrate/low-fat diet (HC/LF group). Daily caloric intake was the same in both groups. Nevertheless, the HC/LF group gained less weight. Despite equivalent degrees of hypertension, hyperglycemia, hyperlipidemia, hyperinsulinemia, and even a poorer glycemic control, the HC/LF group had less severe renal histological abnormalities and a reduced intrarenal advanced glycation and oxidative stress. Mediators of the renoprotection, specifically linked to obesity and body weight control, include a reduced renal inflammation and TGF-beta expression, together with an enhanced level of adiponectin. Altogether, these data identify a specific role of body weight control by a high-carbohydrate/low-fat diet in the progression of DN. Body weight control thus impacts on local intrarenal advanced glycation and oxidative stress through inflammation and adiponectin levels. |
| | |
Authors:
|
Shuichi Ohtomo; Yuko Izuhara; Masaomi Nangaku; Takashi Dan; Sadayoshi Ito; Charles van Ypersele de Strihou; Toshio Miyata |
Related Documents
:
|
3110723 - Effect of the energy source on changes in energy expenditure, respiratory quotient, and... 3046853 - Effect of fat-free diet on insulin requirements in type i diabetes controlled with arti... 2049913 - Restoring nitrogen balance after burn injury. |
Publication Detail:
|
Type: Journal Article Date: 2010-02-17 |
Journal Detail:
|
Title: Journal of obesity (Online) Volume: 2010 ISSN: 2090-0716 ISO Abbreviation: J Obes Publication Date: 2010 |
Date Detail:
|
Created Date: 2010-08-11 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101526295 Medline TA: J Obes Country: Egypt |
Other Details:
|
Languages: eng Pagination: - Citation Subset: - |
Affiliation:
|
Research Division, Chugai Pharmaceutical Co., LTD., Shizuoka 412-8513, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The Association between Childhood Overweight and Reflux Esophagitis.
Next Document: Design, synthesis, and analysis of minor groove binder pyrrolepolyamide-2'-deoxyguanosine hybrids.