Document Detail

Body weight change in women receiving adjuvant chemotherapy for breast cancer: a French prospective study.
MedLine Citation:
PMID:  19713014     Owner:  NLM     Status:  MEDLINE    
BACKGROUND & AIMS: Adjuvant chemotherapy has frequently been associated with weight gain after breast cancer diagnosis. We aimed to prospectively evaluate body weight variations in French patients with early breast cancer. METHODS: This prospective observational study included 272 breast cancer patients who were candidates for adjuvant chemotherapy. Weight and body mass index were measured at baseline visit, then at 9 and 15 months from baseline (6 and 12-month post-chemotherapy). At baseline visit, information on the benefits of weight gain prevention and healthy diet was given by a dietician. Univariate logistic regression was performed to test the association between weight gain and potential predictive factors. RESULTS: Thirty percent of patients gained weight during the year before diagnosis, 26% were overweight and 15% were obese. At one year, the mean weight change was +1.5kg (SD=4.1) and +2.3% (SD=6.0); 60% of the cohort had gained weight, with a median increase of 3.9kg (SD=3.0) and 5.9% (SD=4.4). Reported weight gain during the year before diagnosis appears to be the only factor associated with the absence of post-chemotherapy weight gain (OR=0.54, 95% CI [0.31-0.95], p=0.034). CONCLUSION: Body weight increased in the post-chemotherapy period in French breast cancer survivors, even when given dietary recommendations. Appropriate weight management interventions with nutritional follow-up and physical activity programs are needed.
Olivier Tr?dan; Agathe Bajard; Anne Meunier; Pascale Roux; Ingrid Fiorletta; Th?r?se Gargi; Thomas Bachelot; Jean-Paul Guastalla; Yolande Lallemand; Christelle Faure; David P?rol; Patrick Bachmann
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Publication Detail:
Type:  Clinical Trial; Journal Article     Date:  2009-08-26
Journal Detail:
Title:  Clinical nutrition (Edinburgh, Scotland)     Volume:  29     ISSN:  1532-1983     ISO Abbreviation:  Clin Nutr     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-03-30     Completed Date:  2010-07-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8309603     Medline TA:  Clin Nutr     Country:  England    
Other Details:
Languages:  eng     Pagination:  187-91     Citation Subset:  IM    
Copyright Information:
Copyright 2009 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.
Universit? de Lyon - Centre L?on B?rard, Department of Medical Oncology, 28 rue Laennec, 69008 Lyon, France.
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MeSH Terms
Body Mass Index
Body Weight* / drug effects
Breast Neoplasms / drug therapy*,  pathology,  surgery
Carcinoma / drug therapy*,  pathology,  surgery
Chemotherapy, Adjuvant
Cohort Studies
Early Detection of Cancer
Follow-Up Studies
Middle Aged
Neoplasm Invasiveness
Patient Education as Topic
Prospective Studies
Time Factors
Young Adult

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