| Body temperature rhythms, cold tolerance, and fever in young and old rats of both genders. | |
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MedLine Citation:
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PMID: 2097169 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The circadian rhythm of body temperature (CTR) of male and female rats living at 23 degrees C, as well as their body temperature response to a yeast injection or to a 2-h exposure to 0 degree C, was investigated by telemetry. Young rats had a clear CTR with a mean nocturnal peak of 38.0 +/- 0.1 degree C and diurnal trough of 36.2 +/- 0.1 degree C. Older rats, starting at about 18 months of age, tended to have poor (that is, lower amplitude) rhythms. Mean daily body temperature was 37.1 +/- 0.2 degree C at all ages. After exposure to the cold, the body temperature of young rats, old rats with a strong CTR, and old rats with a poor CTR changed in the ranges of -0.3 to +1.5 degree C, -3.1 to +0.7 degree C, and -5.2 to +0.4 degree C, respectively. This indicates that old animals, especially but not exclusively those with poor CTRs, are less resistant to cold stress. On the other hand, the capacity to develop a fever in response to a yeast injection was equivalent in the three groups of animals, although females had a smaller response than males. It is concluded that the process of aging does not have a generalized debilitating effect on temperature regulation in rats. Rather, aging seems to affect individual components of the thermoregulatory system differentially. |
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Authors:
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R Refinetti; H Ma; E Satinoff |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Experimental gerontology Volume: 25 ISSN: 0531-5565 ISO Abbreviation: Exp. Gerontol. Publication Date: 1990 |
Date Detail:
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Created Date: 1991-07-22 Completed Date: 1991-07-22 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0047061 Medline TA: Exp Gerontol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 533-43 Citation Subset: IM |
Affiliation:
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Department of Psychology, University of Illinois, Champaign 61820. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acclimatization
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physiology Aging / physiology* Animals Body Temperature Regulation / physiology* Circadian Rhythm / physiology* Cold Temperature / adverse effects Female Fever / etiology Male Rats Saccharomyces cerevisiae Sex Characteristics |
| Grant Support | |
ID/Acronym/Agency:
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MH18412/MH/NIMH NIH HHS; MH41138/MH/NIMH NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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