| Body temperature predicts maximum microsatellite length in mammals. | |
| | |
MedLine Citation:
|
PMID: 18522923 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
A long-standing mystery in genome evolution is why short tandem repeats vary so much in length and frequency. Here, we test the hypothesis that body temperature acts to influence the rate and nature of slippage-based mutations. Using the data from both 28 species where genome sequencing is advanced and 76 species from which marker loci have been published, we show that in mammals, maximum repeat number is inversely correlated with body temperature, with warmer-blooded species having shorter 'long' microsatellites. Our results support a model of microsatellite evolution in which maximum length is limited by a temperature-dependent stability threshold. |
| | |
Authors:
|
William Amos; Andrew Clarke |
Related Documents
:
|
17675653 - Using multilocus sequence data to assess population structure, natural selection, and l... 21254333 - Functional interaction between foxd3 and pax3 in cardiac neural crest development. 20006333 - The e32k variant of pcsk9 exacerbates the phenotype of familial hypercholesterolaemia b... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Biology letters Volume: 4 ISSN: 1744-9561 ISO Abbreviation: Biol. Lett. Publication Date: 2008 Aug |
Date Detail:
|
Created Date: 2008-07-08 Completed Date: 2008-09-18 Revised Date: 2013-06-05 |
Medline Journal Info:
|
Nlm Unique ID: 101247722 Medline TA: Biol Lett Country: England |
Other Details:
|
Languages: eng Pagination: 399-401 Citation Subset: IM |
Affiliation:
|
Department of Zoology, University of Cambridge, Cambridge, UK. w.amos@zoo.cam.ac.uk |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Body Temperature / genetics* Cloning, Molecular Evolution, Molecular* Genome Mammals / genetics* Microsatellite Repeats* Models, Genetic |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Phylogenomics reveals a new 'megagroup' including most photosynthetic eukaryotes.
Next Document: Three-dimensional molar enamel distribution and thickness in Australopithecus and Paranthropus.