Document Detail


Body temperature, autonomic responses, and acute mountain sickness.
MedLine Citation:
PMID:  14561242     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A few studies have reported increased body temperature (T(o)) associated with acute mountain sickness (AMS), but these usually include exercise, varying environmental conditions over days, and pulmonary edema. We wished to determine whether T(o) would increase with AMS during early exposure to simulated altitude at rest. Ninety-four exposures of 51 men and women to reduced P(B) (423 mmHg = 16,000 ft = 4850 m) were carried out for 8 to 12 h. AMS was evaluated by LL and AMS-C scores near end of exposure, and T(o) was measured by oral digital thermometer before altitude and after 1 (A1), 6 (A6), and last (A12) h at simulated altitude. Other measurements included ventilation, O(2) consumption and autonomic indicators of plasma catecholamines, HR, and HR variability. Average T(o) increased by 0.5 degrees F from A1 to A12 in all subjects (p < 0.001). Comparison between 16 subjects with lowest AMS scores (mean LL = 1.0, range = 0 to 2.5) and 16 other subjects with highest AMS scores (mean LL = 7.4, range = 5 to 11) demonstrated a transient decline in T(o) from A1 to A6 in AMS, in contrast to a rise in non-AMS (p = 0.001). Catecholamines, HR, and HR variability (increased low F/high F ratio) indicated significant elevation of sympathetic activity in AMS, where T(o) fell, but no change in metabolic rate. The apparently greater heat loss during early AMS suggests increased hypoxic vasodilation in spite of enhanced sympathetic drive. Greater hypoxic vasodilation and elevated HR in AMS in the absence of other changes suggest that augmentation of beta-adrenergic tone may be involved in early AMS pathophysiology.
Authors:
Jack A Loeppky; Milton V Icenogle; Damon Maes; Katrina Riboni; Pietro Scotto; Robert C Roach
Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  High altitude medicine & biology     Volume:  4     ISSN:  1527-0297     ISO Abbreviation:  High Alt. Med. Biol.     Publication Date:  2003  
Date Detail:
Created Date:  2003-10-16     Completed Date:  2004-01-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  100901183     Medline TA:  High Alt Med Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  367-73     Citation Subset:  IM; S    
Affiliation:
Cardiology Section (111B), VA Medical Center, Albuquerque, NM, USA. Loeppky@unm.edu
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MeSH Terms
Descriptor/Qualifier:
Acclimatization / physiology*
Acute Disease
Adult
Altitude
Altitude Sickness / metabolism,  physiopathology*
Arginine Vasopressin / metabolism
Autonomic Nervous System / physiopathology*
Body Temperature / physiology*
Catecholamines / metabolism
Female
Humans
Male
Oxygen Consumption / physiology
Rest / physiology
Chemical
Reg. No./Substance:
0/Catecholamines; 113-79-1/Arginine Vasopressin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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