Document Detail

Body size and risk of Hodgkin's lymphoma by age and gender: a population-based case-control study in Connecticut and Massachusetts.
MedLine Citation:
PMID:  23208661     Owner:  NLM     Status:  MEDLINE    
PURPOSE: Descriptive studies have indicated a rising trend in Hodgkin's lymphoma (HL) incidence in young adults, especially females. Increasing evidence has suggested that some risk factors associated with HL may vary by age or gender. Recent studies have reported an increased risk of HL associated with increasing body mass index (BMI), but the results have been inconsistent. The objectives of this study were to examine whether the associations between measures of body size (height, weight, and BMI) and HL risk vary by age and/or gender.
METHODS: A population-based case-control study was conducted in Connecticut and Massachusetts. A total of 567 HL cases and 679 controls were recruited in 1997-2000. Unconditional logistic regression was used to calculate odds ratios (ORs) and 95 % confidence intervals (CIs).
RESULTS: Among younger women <35 years old, being overweight (25-29.9 kg/m(2)) versus normal weight (18.5-24.9 kg/m(2)) was significantly associated with an increased risk of HL (OR = 2.1, 95 % CI = 1.1-4.0). The risk increased with increasing weight and BMI (p trends <0.01). Among women ≥35 years old, by contrast, higher weight and BMI were associated with a reduced risk of HL (p trends <0.01). Conversely, there was no significant association between BMI and risk of HL in younger or older males.
CONCLUSIONS: These findings show that the associations between body size and risk of HL vary by gender and age, and require confirmation in other populations.
Qian Li; Ellen T Chang; Bryan A Bassig; Min Dai; Qin Qin; Yongshun Gao; Yawei Zhang; Tongzhang Zheng
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2012-12-04
Journal Detail:
Title:  Cancer causes & control : CCC     Volume:  24     ISSN:  1573-7225     ISO Abbreviation:  Cancer Causes Control     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-28     Completed Date:  2013-10-30     Revised Date:  2014-02-04    
Medline Journal Info:
Nlm Unique ID:  9100846     Medline TA:  Cancer Causes Control     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  287-95     Citation Subset:  IM    
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MeSH Terms
Age Factors
Body Mass Index*
Case-Control Studies
Connecticut / epidemiology
Hodgkin Disease / epidemiology*
Massachusetts / epidemiology
Middle Aged
Obesity / epidemiology*
Risk Factors
Sex Factors
Young Adult
Grant Support
D43 TW007864/TW/FIC NIH HHS; D43 TW008323/TW/FIC NIH HHS; D43TW 007864-01/TW/FIC NIH HHS; D43TW 008323/TW/FIC NIH HHS; P01 CA069266-01A1/CA/NCI NIH HHS; T32 CA09001-24/CA/NCI NIH HHS

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