Document Detail


Body shape and size and insulin resistance as early clinical predictors of hyperandrogenic anovulation in ethnic minority adolescent girls.
MedLine Citation:
PMID:  18639784     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: To determine whether key associated features of hyperandrogenic anovulation (HA) in predominately Caribbean Hispanic (CH) adolescent girls can be combined to improve the early diagnosis of HA.
METHODS: Unselected observational sample of females aged 12 to 21 years (mean 17.5 +/- 2.4 years), (64% CH, 28% African American). One hundred twenty subjects provided a menstrual history, had a physical examination, and a follicular phase fasting blood drawn for LH, FSH, testosterone, sex hormone binding globulin (SHBG), 17-OH progesterone (17-OHP), androstenedione (Delta(4)A), glucose, and insulin. We prospectively categorized subjects into four groups: G I (n = 42) had normal menses and normal physical exam; G II (n = 41) had normal menses and abnormal physical exam, that is, signs indicating possible hyperandrogenism and/or insulin resistance, including at least one of obesity, hirsutism, acne, or acanthosis nigricans; G III (n = 15) had abnormal menses and normal physical exam, and G IV (n = 22) had HA with BOTH abnormal menses and abnormal physical exam, that is, girls most likely to develop polycystic ovary syndrome. Hormonal levels and additional clinical and physical characteristics of interest were compared among the four groups.
RESULTS: Group IV subjects had significantly higher waist circumference measurements, independent of overweight status, than all other groups. As hypothesized, Group IV subjects had significantly higher androgen levels and significantly lower SHBG levels than all other groups. FAI, SHBG, and waist circumference had the highest diagnostic accuracy for predicting Group IV status (i.e., HA phenotype).
CONCLUSIONS: Markers of insulin resistance and hyperandrogenemia, including waist circumference, FAI, and SHBG, best associate with irregular menstrual cycles and the HA phenotype in ethnic minority adolescent girls.
Authors:
Jessica Rieder; Nanette Santoro; Hillel W Cohen; Paul Marantz; Susan M Coupey
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Publication Detail:
Type:  Journal Article     Date:  2008-05-19
Journal Detail:
Title:  The Journal of adolescent health : official publication of the Society for Adolescent Medicine     Volume:  43     ISSN:  1879-1972     ISO Abbreviation:  J Adolesc Health     Publication Date:  2008 Aug 
Date Detail:
Created Date:  2008-07-21     Completed Date:  2008-08-20     Revised Date:  2013-06-05    
Medline Journal Info:
Nlm Unique ID:  9102136     Medline TA:  J Adolesc Health     Country:  United States    
Other Details:
Languages:  eng     Pagination:  115-24     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, Division of Adolescent Medicine, Children's Hospital at Montefiore, Albert Einstein College of Medicine, Bronx, New York 10467, USA. jrieder@montefiore.org
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Anovulation / ethnology*
Anthropometry*
Early Diagnosis
Female
Hispanic Americans
Humans
Hyperandrogenism / diagnosis,  ethnology*
Insulin Resistance / ethnology*
New York City
Overweight
Questionnaires
West Indies / ethnology
Grant Support
ID/Acronym/Agency:
M01 RR012248-080059/RR/NCRR NIH HHS; M01 RR012248-090059/RR/NCRR NIH HHS; M01 RR012248-116088/RR/NCRR NIH HHS; R03 HD040821-01/HD/NICHD NIH HHS; R03 HD040821-02/HD/NICHD NIH HHS
Comments/Corrections
Comment In:
J Adolesc Health. 2008 Aug;43(2):103-5   [PMID:  18639782 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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