Document Detail


Body mass index and risk of miscarriage in women with recurrent miscarriage.
MedLine Citation:
PMID:  19439294     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To investigate the effect of underweight, overweight, and obesity on the risk of miscarriage in the subsequent pregnancy in women with recurrent miscarriage. DESIGN: Retrospective analysis of prospectively collected data from the database of a tertiary recurrent miscarriage center. SETTING: The recurrent miscarriage clinic at Sheffield Teaching Hospitals. PATIENT(S): A total of 844 pregnancies from 491 patients with recurrent miscarriage were included in the analysis. MAIN OUTCOME MEASURE(S): The odds of miscarriage in the subsequent pregnancy for all pregnancies after referral to the recurrent miscarriage clinic as well as the first pregnancy post referral. RESULT(S): When analyzing all pregnancies, and compared to women with a normal body mass index, obese and underweight patients had a significantly higher odds of miscarriage in the subsequent pregnancy (OR, 1.71; 95% CI, 1.05-2.8; and OR, 3.98; 95% CI, 1.06-14.92; respectively), whereas there was no significantly increased odds of miscarriage in overweight women (OR, 1.02; 95% CI, 0.72-1.45). Logistic regression analysis showed that the most important factor predicting the occurrence of miscarriage was advanced maternal age (P=0.01) followed by an increased body mass index (P=0.04). CONCLUSION(S): In women with recurrent miscarriage, a mild increase in the body mass index does not increase the risk of miscarriage, whereas obese and underweight patients have a small but significant increased risk of miscarriage in the subsequent pregnancy.
Authors:
Mostafa Metwally; Sotirios H Saravelos; William L Ledger; Tin Chiu Li
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2009-05-12
Journal Detail:
Title:  Fertility and sterility     Volume:  94     ISSN:  1556-5653     ISO Abbreviation:  Fertil. Steril.     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-05-25     Completed Date:  2010-06-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  United States    
Other Details:
Languages:  eng     Pagination:  290-5     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2010 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.
Affiliation:
The Academic Unit of Reproductive and Developmental Medicine, The University of Sheffield and Sheffield Teaching Hospitals, The Jessop Wing, Sheffield, United Kingdom. m.metwally@sheffield.ac.uk
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MeSH Terms
Descriptor/Qualifier:
Abortion, Habitual / diagnosis,  epidemiology*,  etiology
Adult
Body Mass Index*
Databases, Factual / trends
Female
Humans
Obesity / complications,  diagnosis,  epidemiology
Overweight / complications,  diagnosis,  epidemiology*
Pregnancy
Prospective Studies
Retrospective Studies
Risk Factors
Thinness / complications,  diagnosis,  epidemiology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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