Document Detail

Body mass index and risk of miscarriage in women with recurrent miscarriage.
MedLine Citation:
PMID:  19439294     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To investigate the effect of underweight, overweight, and obesity on the risk of miscarriage in the subsequent pregnancy in women with recurrent miscarriage. DESIGN: Retrospective analysis of prospectively collected data from the database of a tertiary recurrent miscarriage center. SETTING: The recurrent miscarriage clinic at Sheffield Teaching Hospitals. PATIENT(S): A total of 844 pregnancies from 491 patients with recurrent miscarriage were included in the analysis. MAIN OUTCOME MEASURE(S): The odds of miscarriage in the subsequent pregnancy for all pregnancies after referral to the recurrent miscarriage clinic as well as the first pregnancy post referral. RESULT(S): When analyzing all pregnancies, and compared to women with a normal body mass index, obese and underweight patients had a significantly higher odds of miscarriage in the subsequent pregnancy (OR, 1.71; 95% CI, 1.05-2.8; and OR, 3.98; 95% CI, 1.06-14.92; respectively), whereas there was no significantly increased odds of miscarriage in overweight women (OR, 1.02; 95% CI, 0.72-1.45). Logistic regression analysis showed that the most important factor predicting the occurrence of miscarriage was advanced maternal age (P=0.01) followed by an increased body mass index (P=0.04). CONCLUSION(S): In women with recurrent miscarriage, a mild increase in the body mass index does not increase the risk of miscarriage, whereas obese and underweight patients have a small but significant increased risk of miscarriage in the subsequent pregnancy.
Mostafa Metwally; Sotirios H Saravelos; William L Ledger; Tin Chiu Li
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2009-05-12
Journal Detail:
Title:  Fertility and sterility     Volume:  94     ISSN:  1556-5653     ISO Abbreviation:  Fertil. Steril.     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-05-25     Completed Date:  2010-06-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  United States    
Other Details:
Languages:  eng     Pagination:  290-5     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2010 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.
The Academic Unit of Reproductive and Developmental Medicine, The University of Sheffield and Sheffield Teaching Hospitals, The Jessop Wing, Sheffield, United Kingdom.
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MeSH Terms
Abortion, Habitual / diagnosis,  epidemiology*,  etiology
Body Mass Index*
Databases, Factual / trends
Obesity / complications,  diagnosis,  epidemiology
Overweight / complications,  diagnosis,  epidemiology*
Prospective Studies
Retrospective Studies
Risk Factors
Thinness / complications,  diagnosis,  epidemiology*

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