| Body mass index, nocturnal fall in blood pressure and organ damage in untreated essential hypertensive patients. | |
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MedLine Citation:
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PMID: 19020422 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: We sought to investigate the relationship between body mass index (BMI) and parameters derived from 48-h ambulatory blood pressure monitoring (ABPM) as well as organ damage in human hypertension. METHODS: A total of 658 consecutive outpatients with grade 1 and 2 hypertension, never treated with antihypertensive medications underwent the following procedures: (i) routine examination, (ii) 24-h urine collection for microalbuminuria, (iii) ABPM over two 24-h periods within 4 weeks, (iv) echocardiography and (v) carotid ultrasonography. Each patient was classified as lean (BMI<25 kg/m2) or overweight/obese (> or =25 kg/m2) and according to the consistency of the dipping or nondipping status in the first and second ABPM period, as dipper (DD), nondipper and variable dipper. RESULTS: Mean 48-h, daytime and nighttime systolic BP or diastolic BP were superimposable in the lean (n=314) and overweight (n=344) group. Overweight patients had a reduced nocturnal BP drop compared with their lean counterparts; the prevalence of DD pattern, indeed, was 15% lower in the overweight group as a whole, with a 17% difference in men and 13% in women. The prevalence of left ventricular hypertrophy was higher in overweight than in lean patients (31.8 vs. 15.9% in men and 48.7 vs. 15.6% in women, P<0.01); this more pronounced cardiac involvement was associated with structural carotid alterations. CONCLUSION: This study, the first to investigate the relationship between BMI and nocturnal BP patterns as assessed by two ABPM sessions, shows that overweight hypertensive patients are more likely to have a reduced nocturnal fall in BP and a greater cardiac and extracardiac organ damage as compared with their lean counterparts despite a similar overall BP load. |
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Authors:
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Cesare Cuspidi; Stefano Meani; Cristiana Valerio; Francesca Negri; Carla Sala; Meilikemu Maisaidi; Valentina Giudici; Alberto Zanchetti; Giuseppe Mancia |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Blood pressure monitoring Volume: 13 ISSN: 1473-5725 ISO Abbreviation: Blood Press Monit Publication Date: 2008 Dec |
Date Detail:
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Created Date: 2008-11-21 Completed Date: 2009-01-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9606438 Medline TA: Blood Press Monit Country: England |
Other Details:
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Languages: eng Pagination: 318-24 Citation Subset: IM |
Affiliation:
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Department of Clinical Medicine and Prevention, University of Milano-Bicocca, Milano, Italy. cesare.cuspidi@unimib.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Albuminuria / physiopathology Blood Pressure / physiology* Blood Pressure Monitoring, Ambulatory Body Mass Index* Carotid Arteries / physiopathology, ultrasonography Circadian Rhythm / physiology* Echocardiography Female Humans Hypertension / physiopathology*, ultrasonography Hypertrophy, Left Ventricular / diagnosis, epidemiology*, ultrasonography Male Middle Aged Outpatients Overweight Prevalence Sex Factors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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