Document Detail

Body mass index and mortality in patients with severe alpha 1-antitrypsin deficiency.
MedLine Citation:
PMID:  9122515     Owner:  NLM     Status:  MEDLINE    
It appears that patients with advanced stages of chronic obstructive pulmonary disease, and particularly emphysema, lose weight and have higher mortality even after controlling for lung function. In the present study, mortality of alpha 1-antitrypsin-deficiency patients PiZ as a function of body mass index (BMI) with control for FEV1, sex and smoking habits was studied. A total of 342 patients participated with a mean follow-up time of 7.6 yr. Ninety patients had BMI under 20 kg m-2, which was the cut-off defining underweight patients. The patients were divided into three groups according to their initial FEV1 % predicted: < 30%, 30-64% and > or = 65%. The underweight patients had significantly higher mortality in the two groups with the lowest FEV1 % predicted. A Cox regression model was applied to control for potential confounders. The risk ratio for the underweight patients was 1.6 (P = 0.03) after controlling for FEV1, age, sex and smoking habits. It is concluded that low body weight is an independent predictor of mortality, but the reason is still unclear.
N Seersholm
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Respiratory medicine     Volume:  91     ISSN:  0954-6111     ISO Abbreviation:  Respir Med     Publication Date:  1997 Feb 
Date Detail:
Created Date:  1997-04-22     Completed Date:  1997-04-22     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8908438     Medline TA:  Respir Med     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  77-82     Citation Subset:  IM    
Department of Respiratory Medicine, Bispebjerg Hospital, Copenhagen, Denmark.
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MeSH Terms
Body Mass Index*
Follow-Up Studies
Forced Expiratory Volume
Lung / physiopathology*
Middle Aged
Smoking / mortality
alpha 1-Antitrypsin Deficiency*

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