| Body mass index-independent inflammation in omental adipose tissue associated with insulin resistance in morbid obesity. | |
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MedLine Citation:
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PMID: 20678967 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Obesity is a strong risk factor for resistance to insulin-mediated glucose disposal, a precursor of type 2 diabetes and other disorders. However, not all obese individuals are insulin resistant. We sought to identify the molecular pathways that might cause obesity-associated insulin resistance in humans by studying the morbidly obese who were insulin sensitive versus insulin resistant, thereby eliminating obesity as a variable. METHODS: Combining gene expression profiling with computational approaches, we determined the global gene expression signatures of omental and subcutaneous adipose tissue samples obtained from similarly obese patients undergoing gastric bypass surgery. RESULTS: Gene sets related to chemokine activity and chemokine receptor binding were identified as most highly expressed in the omental tissue from insulin-resistant compared with insulin-sensitive subjects, independent of the body mass index. These upregulated genes included chemokines (C-C motif) ligand 2, 3, 4, and 18 and interleukin-8/(CC-X motif) ligand 8 and were not differentially expressed in the subcutaneous adipose tissues between the 2 groups of subjects. Insulin resistance, but not the body mass index, was associated with increased macrophage infiltration in the omental adipose tissue, as was adipocyte size, in these morbidly obese subjects. CONCLUSION: Our findings have demonstrated that inflammation of the omental adipose tissue is strongly associated with insulin resistance in human obesity even in subjects with similar body mass index values. |
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Authors:
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Olga T Hardy; Richard A Perugini; Sarah M Nicoloro; Karen Gallagher-Dorval; Vishwajeet Puri; Juerg Straubhaar; Michael P Czech |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2010-06-01 |
Journal Detail:
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Title: Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery Volume: 7 ISSN: 1878-7533 ISO Abbreviation: Surg Obes Relat Dis Publication Date: 2011 Jan-Feb |
Date Detail:
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Created Date: 2011-01-24 Completed Date: 2011-05-24 Revised Date: 2012-04-13 |
Medline Journal Info:
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Nlm Unique ID: 101233161 Medline TA: Surg Obes Relat Dis Country: United States |
Other Details:
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Languages: eng Pagination: 60-7 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 American Society for Metabolic and Bariatric Surgery. Published by Elsevier Inc. All rights reserved. |
Affiliation:
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Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adipocytes
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metabolism,
pathology Adipose Tissue / metabolism*, pathology Adult Body Mass Index* Chemokines / biosynthesis, genetics Female Follow-Up Studies Gene Expression Humans Inflammation / genetics, metabolism*, pathology Insulin Resistance* Male Middle Aged Obesity, Morbid / metabolism*, physiopathology Omentum* Polymerase Chain Reaction RNA / genetics Retrospective Studies |
| Grant Support | |
ID/Acronym/Agency:
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DK30898/DK/NIDDK NIH HHS; DK32520/DK/NIDDK NIH HHS; KL2 RR031981-02/RR/NCRR NIH HHS; P30 DK032520-26/DK/NIDDK NIH HHS; R01 DK030898-28/DK/NIDDK NIH HHS; UL1 RR031982-02/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Chemokines; 63231-63-0/RNA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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