| Body mass index has no effect on rate of progression of chronic kidney disease in subjects with type 2 diabetes mellitus. | |
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MedLine Citation:
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PMID: 22241634 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Background: The incidences of obesity and chronic kidney disease (CKD) are reaching epidemic levels. Recently obesity has been associated with the development of CKD. However, it is unclear whether obesity is a risk factor for the progression of CKD. This study investigated the effect of raised body mass index (BMI, calculated as kg/m2) on the rate of CKD progression in a group of patients with CKD and type 2 diabetes mellitus. Methods: The Chronic Renal Insufficiency Standards Implementation Study (CRISIS) is a large epidemiological study conducted in Manchester, UK. From the CRISIS database, we assessed the rate of progression of CKD in 229 adults who met the inclusion criteria. Baseline measurements such as BMI, estimated glomerular filtration rate (eGFR) and systolic and diastolic blood pressure were collected. eGFR measurements were obtained during follow-up to calculate the rate of eGFR change (?eGFR). Linear regression analysis and independent sample t-test were used in data analysis. Results: After a mean follow-up period of 31 months, linear regression analysis showed no relationship between ?eGFR and BMI. Furthermore, independent sample t-test comparing the obese (BMI =30) and nonobese (BMI <30) groups' ?eGFR showed no statistical significance (p=0.572). Similar results were observed after stratification according to CKD stages 3, 4 and 5. Conclusion: Raised BMI did not influence the rate of progression of chronic kidney disease in patients with type 2 diabetes mellitus. |
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Authors:
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Ali Mohsen; Rebecca Brown; Richard Hoefield; Philip A Kalra; Donal O'Donoghue; Rachel Middleton; David New |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-12-21 |
Journal Detail:
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Title: Journal of nephrology Volume: - ISSN: 1724-6059 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2012-1-13 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9012268 Medline TA: J Nephrol Country: - |
Other Details:
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Languages: ENG Pagination: 0 Citation Subset: - |
Affiliation:
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School of Medicine, The University of Manchester, Manchester - UK. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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