| Body mass index change in females after short-time life style intervention is not dependent on the FTO polymorphisms. | |
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MedLine Citation:
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PMID: 20945953 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Variants within the FTO gene are important determinants of body mass index (BMI), but their role in determination of BMI changes after combined dietary/physical activity intervention is unclear. We have analyzed 107 unrelated overweight non-diabetic Czech females (BMI over 27.5 kg/m(2), age 49.2+/-12.3 years). FTO variants rs17817449 (first intron) and rs17818902 (third intron) were genotyped. The life style modification program (10 weeks) consisted of an age-matched reduction of energy intake and exercise program (aerobic exercise 4 times a week, 60 min each). The mean BMI before intervention was 32.8+/-4.2 kg/m(2) and the mean achieved weight loss was 4.8+/-3.5 kg (5.3+/-3.5 %, max. -15.5 kg, min. +2.0 kg, p<0.01). No significant association between BMI decrease and FTO variants was found. Also waist-to-hip ratio, body composition (body fat, water, active tissue), lipid parameters (total, LDL and HDL cholesterol, triglycerides) glucose and hsCRP changes were independent on FTO variants. FTO variants rs17817449 and rs17818902 are not associated with BMI changes after combined short time dietary/physical activity intervention in overweight females. |
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Authors:
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D Dlouhá; P Suchánek; V Lánskálánskálánská; J A Hubáček |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-10-15 |
Journal Detail:
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Title: Physiological research / Academia Scientiarum Bohemoslovaca Volume: 60 ISSN: 1802-9973 ISO Abbreviation: Physiol Res Publication Date: 2011 |
Date Detail:
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Created Date: 2011-04-07 Completed Date: 2011-08-09 Revised Date: 2011-10-21 |
Medline Journal Info:
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Nlm Unique ID: 9112413 Medline TA: Physiol Res Country: Czech Republic |
Other Details:
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Languages: eng Pagination: 199-202 Citation Subset: IM |
Affiliation:
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Institute for Clinical and Experimental Medicine, Prague, Czech Republic. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adipose Tissue Adult Body Composition Body Mass Index* Cholesterol, LDL / genetics Female Humans Life Style Middle Aged Obesity / genetics Polymorphism, Genetic Proteins / genetics* Triglycerides / genetics Waist-Hip Ratio |
| Chemical | |
Reg. No./Substance:
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0/Cholesterol, LDL; 0/FTO protein, human; 0/Proteins; 0/Triglycerides |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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