Document Detail


Body mass index and blood pressure influences on left ventricular mass and geometry in African Americans: The Atherosclerotic Risk In Communities (ARIC) Study.
MedLine Citation:
PMID:  15184348     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A unique interaction between the influences of body mass index and blood pressure on left ventricular mass index and geometry may contribute to the higher prevalence of left ventricular hypertrophy in African Americans. This cross-sectional study assessed separate and joint influences of body mass index and blood pressure on left ventricular mass index and geometry in 1729 African American participants of the Atherosclerotic Risk in Communities Study. The association between both left ventricular mass index and relative wall thickness and body mass index in each blood pressure category and between these variables and blood pressure in each body mass index category was assessed adjusting for age, diabetes status, hypertension medication, and smoking status. We found that left ventricular hypertrophy and concentric geometry were highly prevalent and that body mass index and blood pressure were independently associated with left ventricular mass index. The adjusted association between blood pressure and left ventricular mass index was stronger with higher body mass index categories; however, there was no significant interaction suggesting merely an additive relationship (not synergistic/multiplicative as tested for in the interaction analysis). Although relative wall thickness was greater with higher categories of body mass index and blood pressure, the mean difference in relative wall thickness between body mass index and blood pressure categories was not statistically significant. The effect on left ventricular geometry as measured by relative wall thickness supports the theory that there is a pathophysiological component in the mechanism of hypertrophy.
Authors:
Ervin Fox; Herman Taylor; Michael Andrew; Hui Han; Emad Mohamed; Robert Garrison; Thomas Skelton
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.     Date:  2004-06-07
Journal Detail:
Title:  Hypertension     Volume:  44     ISSN:  1524-4563     ISO Abbreviation:  Hypertension     Publication Date:  2004 Jul 
Date Detail:
Created Date:  2004-06-25     Completed Date:  2004-09-28     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7906255     Medline TA:  Hypertension     Country:  United States    
Other Details:
Languages:  eng     Pagination:  55-60     Citation Subset:  IM    
Affiliation:
Division of Cardiovascular Diseases, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216-4505, USA. efox@medicine.umsmed.edu
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MeSH Terms
Descriptor/Qualifier:
African Americans*
Aged
Blood Pressure*
Body Mass Index*
Cardiovascular Diseases / epidemiology
Cross-Sectional Studies
Female
Heart Ventricles / anatomy & histology*,  ultrasonography
Humans
Hypertrophy, Left Ventricular / ethnology*,  ultrasonography
Male
Middle Aged
Risk Factors
Grant Support
ID/Acronym/Agency:
N01-HC-55015/HC/NHLBI NIH HHS; N01-HC-55016/HC/NHLBI NIH HHS; N01-HC-55018/HC/NHLBI NIH HHS; N01-HC-55019/HC/NHLBI NIH HHS; N01-HC-55020/HC/NHLBI NIH HHS; N01-HC-55021/HC/NHLBI NIH HHS; N01-HC-55022/HC/NHLBI NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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