Document Detail

Body mass index and associations of sodium and potassium with blood pressure in INTERSALT.
MedLine Citation:
PMID:  8206570     Owner:  NLM     Status:  MEDLINE    
This report further examines the relation of body mass index (BMI) to associations of 24-hour urinary sodium, potassium, and sodium-potassium ratio with blood pressure in INTERSALT, a 52-center international study of electrolytes and blood pressure. Analyses without adjustment for BMI indicated average systolic pressure greater by 6.00 mm Hg per 100 mmol higher sodium and diastolic by 2.52 mm Hg. With adjustment for BMI, these values were reduced to 3.14 and 0.14 mm Hg, respectively. For the sodium-potassium ratio, blood pressure associations were stronger when not adjusted for BMI, and for potassium, adjustment generally had little effect. To explore possible interactions of these variables with BMI in relation to blood pressure, the 52 centers were divided into two groups of 26 based on whether the center median for BMI was less than or greater than or equal to 24.5 kg/m2, and individuals within each of the 52 centers were classified into lower- or higher-BMI groups based on individual BMI less than or greater than or equal to 24.1 kg/m2. Sodium and the sodium-potassium ratio were positively and significantly and potassium inversely and significantly related to systolic pressure in all four of these subgroups, and the sodium-potassium ratio and potassium were related to diastolic pressure in two and three subgroups, respectively. Electrolyte-blood pressure associations did not differ significantly between the two subgroups of centers or between the two subgroups based on individuals.(ABSTRACT TRUNCATED AT 250 WORDS)
A R Dyer; P Elliott; M Shipley; R Stamler; J Stamler
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Hypertension     Volume:  23     ISSN:  0194-911X     ISO Abbreviation:  Hypertension     Publication Date:  1994 Jun 
Date Detail:
Created Date:  1994-07-11     Completed Date:  1994-07-11     Revised Date:  2009-09-29    
Medline Journal Info:
Nlm Unique ID:  7906255     Medline TA:  Hypertension     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  729-36     Citation Subset:  IM    
Department of Preventive Medicine, Northwestern University Medical School, Chicago, Ill. 60611.
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MeSH Terms
Blood Pressure*
Body Mass Index*
International Cooperation
Middle Aged
Potassium / urine*
Statistics as Topic
Grant Support
2R01 HL-33387/HL/NHLBI NIH HHS; //Wellcome Trust
Reg. No./Substance:

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