Document Detail

Body height and blood pressure regulation in humans during anti-orthostatic tilting.
MedLine Citation:
PMID:  22338081     Owner:  NLM     Status:  Publisher    
The hypothesis was tested that the cardiovascular changes during an upper body anti-orthostatic maneuver in humans are more pronounced in tall than in short individuals, because of the larger intravascular hydrostatic pressure gradients. In 34 males and 41 females (20 - 30 y, BH = 147 - 206 cm), inter-individual multiple linear regression analyses adjusted for gender and body weight were conducted between changes in cardiovascular variables versus body height during tilting of the upper body from vertical to horizontal while keeping the legs horizontal. In all the subjects, tilting induced increases in stroke volume and arterial pulse pressure and a decrease in heart rate, which each correlated significantly with body height. In males (n = 51, BH = 163 - 206 cm), 24-h ambulatory mean arterial pressure increased significantly with body height (p = 0.004, r = 0.40, α = 0.15 mmHg(-1)cm(-1)) so that systolic /diastolic blood pressure increased by 2/2 mm Hg per 15 cm increase in body height. There was no significant correlation between mean arterial pressure and body height in females (n = 53, BH = 147 - 193 cm). In conclusion, a larger body height induces larger cardiovascular changes during anti-orthostatic tilting, and in males 24-h ambulatory mean arterial pressure increases with body height. The lack of a mean arterial pressure to body height correlation in females is probably because of their lower body height and greater variability in blood pressure.
Sine Kongsbak Arvedsen; Morten Damgaard; Peter Norsk
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-2-15
Journal Detail:
Title:  American journal of physiology. Regulatory, integrative and comparative physiology     Volume:  -     ISSN:  1522-1490     ISO Abbreviation:  -     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-2-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100901230     Medline TA:  Am J Physiol Regul Integr Comp Physiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
1University of Copenhagen, DK-2200 Copenhagen, Denmark.
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