Document Detail

Body fluid changes in hypertensive rats. Their modifications by saline load.
MedLine Citation:
PMID:  503266     Owner:  NLM     Status:  MEDLINE    
Subtotal nephrectomy was produced in male Wistar rats and the evolution of arterial pressure, water distribution and electrolytic composition of muscle and arterial tissue were studied. Also, the modifications produced by a chronic administration of saline load were evaluated. The incidence of hypertension is higher in the group that received saline load but the levels of the blood pressure were similar in both groups of hypertensive animals. The total water is increased in all the groups, except at the fourth week in the animals that did not receive saline load, in which it was decreased. The extracellular space is augmented in all groups and the plasma volume increased in the early phases of the experimental period with exception of the normotensive rats without saline load. No alterations were observed in the electrolytic muscle content, and the total water and potassium and chloride content of the arterial tissues was increased without modifications in the sodium content. The possible relationship of these alterations with the development of hypertension are discussed.
A Martinez Seeber; C T Arranz
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Nephron     Volume:  24     ISSN:  0028-2766     ISO Abbreviation:  Nephron     Publication Date:  1979  
Date Detail:
Created Date:  1980-01-28     Completed Date:  1980-01-28     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0331777     Medline TA:  Nephron     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  241-5     Citation Subset:  IM    
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MeSH Terms
Body Fluid Compartments / drug effects
Body Fluids / drug effects*
Body Water / drug effects
Electrolytes / metabolism
Extracellular Space / drug effects
Hypertension / physiopathology*
Intracellular Fluid / drug effects
Inulin / metabolism
Plasma Volume / drug effects
Sodium Chloride / pharmacology*
Reg. No./Substance:
0/Electrolytes; 7647-14-5/Sodium Chloride; 9005-80-5/Inulin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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