| Body fatness and sex steroid hormone concentrations in US men: results from NHANES III. | |
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MedLine Citation:
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PMID: 21678033 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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OBJECTIVE: Obesity is associated with a variety of chronic diseases, including cancer, which may partly be explained by its influence on sex steroid hormone concentrations. Whether different measures of obesity, i.e., body mass index (BMI), waist circumference, and percent body fat were differentially associated with circulating levels of sex steroid hormones was examined in 1,265 men, aged 20-90+ years old, attending the morning examination session of the Third National Health and Nutrition Examination Survey (NHANES III). MATERIALS AND METHODS: Serum hormones were measured by immunoassay. Weight, height, and waist circumference were measured by trained staff. Percent body fat was estimated from bioelectrical impedance. Multivariate linear regression was used to estimate associations between body fatness measures and hormone levels. RESULTS: Total and free testosterone and sex hormone binding globulin concentrations decreased, whereas total and free estradiol increased with increasing BMI, waist circumference, and percent body fat (all p trend < 0.05). The magnitude of change in these hormones was similar for a one-quartile increase in each body fatness measure. CONCLUSION: Measured BMI, waist circumference, and percent body fat led to similar inferences about their association with hormone levels in men. |
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Authors:
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Sabine Rohrmann; Meredith S Shiels; David S Lopez; Nader Rifai; William G Nelson; Norma Kanarek; Eliseo Guallar; Andy Menke; Corinne E Joshu; Manning Feinleib; Siobhan Sutcliffe; Elizabeth A Platz |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-6-16 |
Journal Detail:
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Title: Cancer causes & control : CCC Volume: - ISSN: 1573-7225 ISO Abbreviation: - Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2011-6-16 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9100846 Medline TA: Cancer Causes Control Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Institute of Social and Preventive Medicine, University of Zurich, Hirschengraben 84, 8001, Zürich, Switzerland, sabine.rohrmann@ifspm.uzh.ch. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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