Document Detail

Body fat reserves attenuate gastric ulcers induced by restricted feeding in rats.
MedLine Citation:
PMID:  8778889     Owner:  NLM     Status:  MEDLINE    
The purpose of this experiment was to explicitly test the hypothesis that the depletion of fat reserves is a critical factor in the generation of ulcers in the glandular stomach. Fat reserves were systematically manipulated by using chow vs. high-fat diets and by using rats of different ages (3, 7, and 17 months). The ulcerogenic procedure consisted of limiting food intake to 6 g of chow per day. For chow-fed rats, 20 days were required to induce ulcers in 3-month-old rats whereas more than 40 days were required in 7- and 17-month-old rats. In 7-month-old rats fed a high-fat diet, the ulcerogenic phase lasted 63 days. Virtually no ulcers were found in control groups with larger body weights that were yoked to the duration of the ulcerogenic phase. Measurement of retroperitoneal and epididymal fat pads indicated that these were nearly depleted in rats with ulcers whereas some fat remained in ulcer-free rats, regardless of age, diet, or the duration of the ulcerogenic phase. These results suggest that the depletion of fat reserves to a critical level triggers a metabolic stress response that then produces gastric ulcers.
I Yi; F K Stephan
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Physiology & behavior     Volume:  59     ISSN:  0031-9384     ISO Abbreviation:  Physiol. Behav.     Publication Date:    1996 Apr-May
Date Detail:
Created Date:  1996-09-13     Completed Date:  1996-09-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0151504     Medline TA:  Physiol Behav     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  931-6     Citation Subset:  IM    
Department of Psychology, Florida State University, Tallahassee 32306-1051, USA.
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MeSH Terms
Adipose Tissue / physiology*
Aging / physiology
Body Composition / physiology
Body Weight / physiology
Eating / physiology*
Epididymis / physiology
Obesity / physiopathology
Rats, Sprague-Dawley
Retroperitoneal Space / physiology
Stomach Ulcer / physiopathology*
Weight Loss / physiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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