Document Detail

Body fat distribution and metabolic consequences - examination opportunities in dogs.
MedLine Citation:
PMID:  24334077     Owner:  NLM     Status:  Publisher    
The relationship between metabolic disorders and the distribution of fat in different body regions is not clearly understood in humans. The aim of this study was to develop a suitable method for assessing the regional distribution of fat deposits and their metabolic effects in dogs. Twenty-five dogs were subjected to computed tomographic (CT) imaging and blood sampling in order to characterise their metabolic status. The different fat areas were measured on a cross-sectional scan, and the animals' metabolic status was evaluated by measuring fasting glucose, insulin and leptin levels. The volume of visceral adipose tissue is the main determinant of leptin levels. The correlation of visceral fat volume and leptin concentration was found to be independent of insulin levels or the degree of insulin resistance. There was a positive correlation between the visceral to subcutaneous fat volume ratio and serum insulin concentration, and a similar trend was observed in the relationship of fat ratio and insulin resistance. The distribution of body fat essentially influences the metabolic parameters in dogs, but the effects of adiposity differ between humans and dogs. The findings can facilitate a possible extrapolation of results from animal studies to humans with regard to the metabolic consequences of different obesity types.
Linda Müller; Eszter Kollár; Lajos Balogh; Zita Pöstényi; Teréz Márián; Ildikó Garai; László Balkay; György Trencsényi; Julianna Thuróczy
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-12-11
Journal Detail:
Title:  Acta veterinaria Hungarica     Volume:  -     ISSN:  0236-6290     ISO Abbreviation:  Acta Vet. Hung.     Publication Date:  2013 Dec 
Date Detail:
Created Date:  2013-12-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8406376     Medline TA:  Acta Vet Hung     Country:  -    
Other Details:
Languages:  ENG     Pagination:  1-11     Citation Subset:  -    
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