Document Detail


Body fat distribution, liver enzymes, and risk of hypertension: evidence from the Western New York Study.
MedLine Citation:
PMID:  16203871     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Gamma-glutamyltransferase (GGT) has been associated with hypertension (HTN); however, the nature of this association remains unclear. GGT is a marker of alcohol consumption, but it is also related to the infiltration of fat in the liver (fatty liver). The association between GGT and HTN was examined in a 6-year longitudinal investigation among 1455 men and women who returned for the follow-up visit. Baseline variables included serum GGT, blood pressure, and anthropometric measures. Incident HTN was defined as blood pressure > or =140/90 or on antihypertensive medication at the follow-up visit. To eliminate individuals with potential liver pathology, analyses focused only on individuals with GGT within its normal range (n=897). Participants were divided in quintiles (Q) based on their baseline GGT levels. Multiple logistic regression analyses [odds ratio (95% confidence intervals)] revealed a significant association of GGT with incident hypertension [2.1 (1.1 to 4.0) Q5 versus Q1]. In subgroup analyses, GGT and HTN were significantly associated among both noncurrent and current drinkers, but only for participants above the median of anthropometric measures [eg, body mass index >26.4, 2.3 (0.9 to 5.7), waist circumference >86.1 cm, 3.7 (1.4 to 9.9), and abdominal height >19.8 cm, 3.1 (1.2 to 8.5), for Q5 versus Q1, in fully adjusted models]. These findings suggest that the association between GGT and hypertension is not caused solely by alcohol consumption and indicate that serum GGT, within its normal range, may predict hypertension among individuals with increased central fat distribution, suggesting that fatty liver may represent an important underlying mechanism for this association.
Authors:
Saverio Stranges; Maurizio Trevisan; Joan M Dorn; Jacek Dmochowski; Richard P Donahue
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.     Date:  2005-10-03
Journal Detail:
Title:  Hypertension     Volume:  46     ISSN:  1524-4563     ISO Abbreviation:  Hypertension     Publication Date:  2005 Nov 
Date Detail:
Created Date:  2005-10-28     Completed Date:  2005-12-29     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7906255     Medline TA:  Hypertension     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1186-93     Citation Subset:  IM    
Affiliation:
Department of Social & Preventive Medicine, State University of New York at Buffalo, NY 14214, USA. stranges@buffalo.edu
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Alcohol Drinking / adverse effects
Anthropometry
Blood Pressure
Body Fat Distribution*
Female
Follow-Up Studies
Humans
Hypertension / etiology*
Liver / enzymology*
Logistic Models
Longitudinal Studies
Male
Middle Aged
Risk Assessment
gamma-Glutamyltransferase / blood
Grant Support
ID/Acronym/Agency:
R01 DK60587/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
EC 2.3.2.2/gamma-Glutamyltransferase
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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